目的 研究普羅布考聯(lián)合阿魏酸哌嗪片治療糖尿病腎病的臨床療效。方法 選擇2012年3—2014年9月在天津市濱海新區(qū)大港醫(yī)院收治的糖尿病腎病患者80例,隨機(jī)分為對照組和治療組,每組各40人。所有患者均給予糖尿病腎病的常規(guī)治療。在此基礎(chǔ)上,對照組餐后30 min口服阿魏酸哌嗪片,4片/次,3次/d。治療組口服普羅布考片,4片/次,2次/d,阿魏酸哌嗪片的用法用量同對照組。兩組均連續(xù)治療12周。比較兩組的臨床療效,同時(shí)比較兩組治療前后胱抑素C(Cys C)、高敏C反應(yīng)蛋白(hs-CRP)、轉(zhuǎn)換生長因子β₁(TGF-β₁)、尿微量白蛋白排泄率(UAER)、血清肌酐(Scr)、丙二醛(MDA)、血尿素氮(BUN)、尿β₂微球蛋白(β₂-MG)變化情況。結(jié)果 對照組和治療組總有效率分別為72.5%、87.5%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05)。治療后,兩組各觀察指標(biāo)均有所改善,其中Cys C、hs-CRP、TGF-β₁、UAER、SCr、MDA、BUN、β₂-MG顯著降低,同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P < 0.05)。結(jié)論 普羅布考聯(lián)合阿魏酸哌嗪片治療糖尿病腎病具有較好的臨床療效,可以有效抑制炎癥發(fā)生過程、減輕蛋白尿,為糖尿病腎病的治療提供了新方法。

objective To investigate the clinical effect of probucol combined with Piperazine Ferulate Tablets in treatment of diabetic nephropathy. Methods The patients with diabetic nephropathy (80 cases) of Dagang Hospital of Tianjin Binhai New Area from March 2012 to September 2014 were randomly divided into control and treatment groups, and each group had 40 cases. All patients were given conventional treatment of diabetic nephropathy. The patients in the control group were po administered with Piperazine Ferulate Tablets 30 min after meal, 4 tablets/time, three times daily. The patients in the treatment group were po administered with Probucol Tablets, 4 tablets/time, twice daily, and the usage and dosage of Piperazine Ferulate Tablets were the same as the control group. The patients in two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, and the changes of Cys C, hs-CRP, TGF-β₁, UAER, SCr, MDA, BUN, and β₂-MG were compared. Results The efficacies in the control and treatment groups were 72.5% and 87.5%, respectively, and there were differences between two groups (P < 0.05). After treatment, Cys C, hs-CRP, TGF-β₁, UAER, SCr, MDA, BUN, and β₂-MG were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Probucol combined with Piperazine Ferulate Tablets has the good clinical effect in treatment of diabetic nephropathy, and can effectively restrain the inflammation process, while can reduce proteinuria, which provides a new way for the treatment of diabetic nephropathy.