目的 調(diào)查分析2011—2014年東營市人民醫(yī)院門診麻醉藥品的應(yīng)用情況及趨勢,為麻醉藥品的科學管理和合理應(yīng)用提供參考。方法 采用回顧性方法,對4 526張門診麻醉處方的用藥數(shù)量、用于癌痛的構(gòu)成比、限定日劑量(DDD)值、用藥頻度(DDDs)及藥物利用指數(shù)(DUI)等數(shù)據(jù)進行統(tǒng)計與分析。結(jié)果 處方中共應(yīng)用9種麻醉類鎮(zhèn)痛藥物,2011—2014年中藥品用量均為前兩位的分別是硫酸嗎啡控釋片和鹽酸羥考酮緩釋片(20 mg/片);鹽酸哌替啶注射液用量呈逐年下降趨勢,到2012年已經(jīng)不用于癌痛治療;DDDs排前兩位的分別是鹽酸羥考酮緩釋片(20 mg/片)和硫酸嗎啡控釋片,鹽酸布桂嗪注射液的DDDs一直最低。鹽酸哌替啶注射液和芬太尼透皮貼的DUI值均≤1,硫酸嗎啡控釋片的DUI值均 > 1,其他的DUI約為1,且變化不明顯。結(jié)論 東營市人民醫(yī)院門診麻醉藥品的管理較規(guī)范,癌痛治療藥物結(jié)構(gòu)日趨規(guī)范。

Objective To investigate and analyze the application situation and trend of narcotic drugs in outpatient department of People's Hospital of Dongying City during 2011 — 2014, in order to provide reference for scientific management and reasonable application of narcotic drugs. Methods The usage of narcotic drugs in outpatient department to patients (4 526 cases) was summarized retrospectively, and drug dosage, constituent ratio of narcotic drugs for cancer pain relief, defined daily dose (DDD), frequency of drug use (DDDs), and drug utilization index (DUI) were analyzed statistically. Results Nine kinds of narcotic drugs were used. The top two narcotic drugs in drug dosage were Morphine Sulfate Controlled-release Tablets (MST) and Oxycodone Hydrochloride Prolonged-release Tablets (20 mg/tablet). The amount of Pethidine Hydrochloride Injection decreased every year, and was not used for treatment of cancer pain in 2012. The top two narcotic drugs in DDDs were Oxycodone Hydrochloride Prolonged-release Tablets (20 mg/tablet) and MST. DDDs of Bucinnazine Hydrochloride Injection and Fentanyl Transdermal Patch was the lowest. The DUI index of Pethidine Hydrochloride Injection and Fentanyl Transdermal Patch were both less than 1, and the DUI index of MST was more than 1. Others were equal to 1, and the changes were not obvious. Conclusion The use of narcotic drugs in outpatient department of People's Hospital of Dongying City is rational basically, and the structure of drugs used for cancer pain relief is becoming more balanced.