痛風(fēng)是一種代謝性疾病,危害嚴(yán)重,近年來患病率呈上升趨勢。尿酸排泄減少或生成增多所致的高尿酸血癥是痛風(fēng)的主要病因,而高尿酸又與多種疾病密切相關(guān)。降低血尿酸水平是治療痛風(fēng),預(yù)防痛風(fēng)復(fù)發(fā)的重要措施。目前,抗高尿酸血癥藥物主要有3類,分別是黃嘌呤氧化酶抑制劑、尿酸鹽陰離子轉(zhuǎn)運(yùn)蛋白1(URAT1)抑制劑和尿酸氧化酶類似物。對現(xiàn)有抗高尿酸血癥藥物的現(xiàn)狀以及研究進(jìn)展進(jìn)行總結(jié),希望對其研發(fā)提供參考。

Gout is a metabolic disease, and does serious harm to human beings. In recent years, gout prevalence rate assumes upwards trend. Hyperuricemia caused by decreased uric acid excretion or increased formation of uric acid may account for gout. While high uric acid is closely related to various diseases. Therefore reducing blood uric acid level is the important measure to treat gout and prevent the recurrence of gout. So far, there are three kinds of anti-hyperuricemic drugs, including xanthine oxidase inhibitors, Urate anion exchanger 1 (URAT1) inhibitors, and urate oxidase analogues. The present situation and research progress of anti-hyperuricemic drugs are reviewed in this paper, in order to provide a reference for the development of anti-hyperuricemic drugs.