目的 研究新癀片對不同動物模型的解熱作用.方法 制備酵母致大鼠發(fā)熱、牛奶致家兔發(fā)熱、內毒素致家兔發(fā)熱模型測量給藥后各組的體溫,計算各組大鼠體溫與基礎體溫差值以及各給藥組降溫率.結果 新癀片95.0 mg/kg劑量組在藥后1～4.5 h,47.5 mg/kg劑量組藥后4、4.5 h對酵母所致大鼠體溫升高有顯著的抑制作用.藥后1 h,新癀片47.5 mg/kg劑量組牛奶致發(fā)熱家兔體溫開始下降;藥后2 h,47.5、23.8 mg/kg劑量組家兔體溫均下降顯著,一直持續(xù)到藥后5 h,仍有顯著的降溫作用.新癀片47.5 mg/kg劑量能夠顯著降低內毒素致發(fā)熱家兔各時間點體溫的升高,在藥后4、5 h時對體溫的降溫率達50.3%、85.2%.結論 新癀片對酵母致大鼠發(fā)熱、牛奶致家兔發(fā)熱和內毒素致家兔發(fā)熱均有很好的解熱作用.

Objective To research the antipyretic effects of Xinhuang Tablets on different animal fever models. Methods The rats fever model of yeast-induced, the rabbits fever models of milk-induced and endotoxin-induced were prepared, and body temperatures of animals were measured. The difference of each group between body temperature and basal body temperature and temperature drop rates were calculated. Results Xinhuang Tablets could significantly inhibit rise of body temperature of yeast-caused fever in rats after ig administered during 1-4.5 h at dosage of 95.0 mg/kg, and after ig administered 4 and 4.5 h at dosage of 47.5 mg/kg. The rabbit body temperatures in Xinhuang Tablets 47.5 mg/kg dose group milk-induced fever began to decline after ig administered 1 h, and those in Xinhuang Tablets 47.5, 23.8 mg/kg dose groups both significantly decreased after ig administered 2 h, until 5 h. Xinhuang Tablets could significantly decline the rise of body temperatures in rabbits endotoxin-induced fever at dosage of 47.5 mg/kg each time points, and the temperature drop rates reached 50.3% and 85.2% after ig administered 4 and 5 h. Conclusion Xinhuang Tablets has significant antipyretic effects on rats fever model of yeast-induced, the rabbits fever models of milk-induced and endotoxin-induced.