目的 比較厄貝沙坦氫溴酸鹽與厄貝沙坦的毒性和藥效.方法 采用無創(chuàng)血壓測量比較了厄貝沙坦氫溴酸鹽、厄貝沙坦對自發(fā)性高血壓大鼠血壓的影響.分別ip、ig給藥,觀察兩種藥物的半數致死量(LD₅₀),對心率、呼吸以及動物自主活動的影響.結果 自發(fā)性高血壓大鼠的血壓明顯高于非自發(fā)性高血壓大鼠,給予厄貝沙坦氫溴酸鹽、厄貝沙坦后血壓均降至正常水平,且兩種藥物的降壓作用差異無顯著性,但厄貝沙坦氫溴酸鹽的藥效持續(xù)時間更長.厄貝沙坦氫溴酸鹽、厄貝沙坦對動物的呼吸、心率以及自主活動的影響無差異,但厄貝沙坦氫溴酸鹽的LD₅₀明顯高于厄貝沙坦.結論 厄貝沙坦氫溴酸鹽具有和厄貝沙坦相同的降壓作用,但是作用時間更長,安全性更高.

Objective To compare toxicity and pharmacodynamics between irbesartan and irbesartan hydrobromate. Methods Blood pressures in spontaneously hypertensive rats (SHR) after administered with irbesartan and irbesartan hydrobromate were compared using noninvasive blood pressure. SHR were ip and ig administered with drugs, and effects on heart rate, respiratory rate, and autonomic activities were observed. Results Blood pressure in SHR was higher than that of non spontaneous hypertensive rats. Both irbesartan hydrobromate and irbesartan could lower blood pressure, and there were no differences between two groups, but duration of irbesartan hydrobromate was longer. There was no difference between two groups on heart rate, respiratory rate, and autonomic activities. LD₅₀ value of irbesartan hydrobromate was higher than that of irbesartan. Conclusion Irbesartan hydrobromate has anti-hypertensive effect as well as irbesartan, but with longer duration and higher security.

南開大學本科生創(chuàng)新科研計劃項目(BX9-230)