目的 研究螺旋藻膠囊聯(lián)合紫杉醇、順鉑治療晚期宮頸癌的的臨床效果.方法 收集2011年3月—2014年1月遼寧省腫瘤醫(yī)院收治的晚期宮頸癌患者90例,隨機(jī)分為對照組與治療組,每組例45例.對照組患者在每個化療周期的第1天靜脈滴注紫杉醇注射液130 mg/m²,靜脈滴注注射用順鉑60 mg/m².治療組口服螺旋藻膠囊,3粒/次,3次/d,其他治療同對照組.兩組21 d為1個化療療程,均連續(xù)治療4個療程.觀察兩組患者治療的臨床療效,比較兩組Karnofsky(KPS)評分、免疫功能指標(biāo)的變化,同時觀察兩組藥物的不良反應(yīng)發(fā)生情況.結(jié)果 治療后,對照組和治療組的總有效率分別為71.11%、88.89%,兩組比較差異有統(tǒng)計學(xué)意義(P< 0.05).治療組患者經(jīng)過治療后KPS評分、CD³⁺、CD⁴⁺高于治療前,CD⁸⁺低于治療前,同組比較差異有統(tǒng)計學(xué)意義(P< 0.05).治療組患者治療后Karnofsky評分、CD³⁺、CD⁴⁺高于對照組,CD⁸⁺低于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05).治療過程中,兩組患者均可發(fā)生白細(xì)胞降低、血小板減少、惡心嘔吐、腹瀉、貧血、口腔黏膜炎癥等毒副反應(yīng),但治療組的發(fā)生率低于對照組,兩組比較差異有統(tǒng)計學(xué)意義(P< 0.05).結(jié)論 螺旋藻膠囊聯(lián)合紫杉醇、順鉑治療晚期宮頸癌能提高患者的臨床療效,改善患者的生活質(zhì)量,提高患者的免疫功能,還可減少化療藥物的毒副作用,值得在臨床上進(jìn)一步推廣應(yīng)用.

Objective To explore the clinical effect of Spirulina Capsules combined with paclitaxel and cisplatin in treatment of advanced cervical cancer. Methods The patients with advanced cervical cancer (90 cases) of Liaoning Cancer Hospital & Institute from March 2011 to January 2014 were randomly divided into control and treatment groups, and each group had 45 cases. The patients in the control group were iv administered with Paclitaxel Injection 130 mg/m² and Cisplatin for injection 60 mg/m² on the first day of each chemotherapy cycle. The patients in the treatment group were po administered with Spirulina Capsules, 3 grains/time, three times daily, and other treatment was the same as the control group. One course of treatment was 21 d, and two groups were treated for four courses of chemotherapy. After treatment, the efficacy was evaluated, and the changes of KPS score and immune function indexes were compared. At the same time, drug adverse reactions of two groups were observed. Results After treatment, the total effective rate of control and treatment groups were 71.11% and 88.89%, respectively, and there were differences between two groups (P <0.05). After treatment, KPS score, CD³⁺, CD⁴⁺ in the treatment group were higher than those before the treatment, while CD⁸⁺ was significantly reduced, and the difference was statistically significant in the same group (P <0.05). After treatment CD³⁺, CD⁴⁺ were higher than those in the control group, and CD⁸⁺ was lower than that in the control group, and there were differences between two groups (P <0.05). The incidences of adverse reaction such as white blood cells and platelets reduced, nausea, vomiting, diarrhea, anemia, and inflammation of the oral mucosa were significantly lower than those in the control group. Conclusion Spirulina Capsules combined with paclitaxel and cisplatin can improve the clinical curative effect of advanced cervical cancer, and can improve the quality of life and immune function, while can reduce the adverse reaction of chemotherapy drugs, which is worth clinical popularization and application.