目的 探討孟魯司特鈉咀嚼片聯合糠酸莫米松鼻噴霧劑治療兒童過敏性鼻炎的臨床療效.方法 選擇2013年10月—2014年5月在重慶市中醫(yī)院就診的過敏性鼻炎患兒96例,隨機分為對照組和治療組,每組48例.對照組患兒使用糠酸莫米松鼻噴霧劑,每側鼻孔100 μg/次,1次/d.治療組患兒在對照組的治療基礎上口服孟魯斯特鈉咀嚼片,5 mg/次,1次/d.兩組患兒均連續(xù)治療14 d.觀察兩組的臨床療效,比較兩組患者鼻炎總體癥狀、流涕、鼻癢、噴嚏、鼻塞等評分的變化,同時檢測兩組白細胞介素10(IL-10)、干擾素γ(IFN-γ)、IL-4、IgE的變化.結果 治療后,對照組和治療組的總有效率分別為87.5%、100.0%,兩組總有效率比較差異有統(tǒng)計學意義(P< 0.05).治療7、14 d兩組患兒噴嚏、流涕、鼻塞、鼻癢評分、癥狀總評分均較治療前顯著降低,同組治療前后差異有統(tǒng)計學意義(P< 0.05);且治療組的改善程度優(yōu)于對照組,兩組比較差異有統(tǒng)計學意義(P< 0.05).治療后,兩組患兒的IL-4、IgE顯著降低,IL-10、IFN-γ水平均有明顯升高,同組治療前后差異有統(tǒng)計學意義(P< 0.05);但治療組這些檢測因子的改善程度優(yōu)于對照組,兩組比較差異有統(tǒng)計學意義(P< 0.05).結論 孟魯司特鈉咀嚼片聯合糠酸莫米松鼻噴霧劑治療兒童過敏性鼻炎具有較好的臨床療效,可有效降低癥狀評分,調節(jié)鼻炎相關因子水平,值得臨床推廣應用.

Objective To explore the clinical effect of Montelukast Sodium Chewable Tablets combined with Mometasone Furoate Aqueous Nasal Spray in treatment of allergic rhinitis of children. Methods The patients with allergic rhinitis (96 cases) of the Hospital of Traditional Chinese Medicine in Chongqing from October 2013 to May 2014 were randomly divided into control and treatment groups, and each group had 48 cases. The patients in the control group were given Mometasone Furoate Aqueous Nasal Spray, both nostril 100 μg/time, once daily. The patients in the treatment group were po administered with Montelukast Sodium Chewable Tablets on the basis of the treatment in the control group, 5 mg/time, once daily. Both groups were treated for 14 d. After treatment, the efficacy was evaluated, changes of rhinitis general symptoms, runny nose, nasal itching, sneezing, and nasal congestion scores in two groups were compared. At the same time, IL-10, IFN-γ, IL-4, and IgE in two groups were detected. Results After treatment, the total effective rate of control and treatment groups were 87.5% and 100.0%, respectively, and there were differences between two groups (P <0.05). General symptoms, runny nose, nasal itching, sneezing, and nasal congestion scores in two groups on the 7 and 14 d of treatment was significantly reduced, and the difference was statistically significant in the same group (P <0.05). And these indicators in treatment group improved better than those in the control group, with significant difference between two groups (P <0.05). After treatment, IL-4 and IgE in two groups were significantly reduced, while IL-10 and IFN-γ were significantly increased, and the difference was statistically significant in the same group (P <0.05). The improvement of detection factor in the treatment group was better than those in the control group, and there were differences between two groups (P <0.05). Conclusion Montelukast Sodium Chewable Tablets combined with Mometasone Furoate Aqueous Nasal Spray has the good clinical effect in treatment of allergic rhinitis of children, and can effectively reduce the symptom scores, while can adjust the rhinitis correlation factors, which is worth clinical promotion.