目的 探討選擇性5-羥色胺再攝取抑制劑(SSRI)致藥品不良反應(yīng)(ADR)的規(guī)律和特點(diǎn),為臨床合理用藥提供參考。方法 檢索2004年1月－2014年12月中國期刊全文數(shù)據(jù)庫(CNKI)、萬方數(shù)字化期刊全文庫、中文科技期刊全文數(shù)據(jù)庫(維普)、中國醫(yī)院知識(shí)總庫(CHKD)等數(shù)據(jù)庫報(bào)道的SSRI致ADR的文獻(xiàn),并進(jìn)行分析和討論。結(jié)果 SSRI引發(fā)的ADR女性明顯多于男性,年齡多集中于41～60歲;抑郁癥發(fā)生的ADR例數(shù)最多;在引發(fā)ADR的SSRI中,帕羅西汀的發(fā)生率最高;服藥4周后出現(xiàn)ADR的例數(shù)最多,占30.5%;有25例聯(lián)合用藥,其中帕羅西汀聯(lián)合用藥的例數(shù)最多;SSRI引發(fā)的ADR以神經(jīng)系統(tǒng)損害為主,占44.9%。結(jié)論 SSRI引發(fā)的ADR較為常見,臨床使用時(shí)應(yīng)及時(shí)處理,以確保患者用藥安全。

Objective To explore the rules and characteristics of adverse drug reaction (ADR) induced by selective serotonin reuptake inhibitor (SSRI), and to provide the references for the rational use of drugs in clinic. Methods China Journal Full-text Database (CNKI), Wangfang Database, Chinese Science and Technology Journal Full-text Database (VIP), China Hospital Knowledge Database (CHKD), etc were retrieved from January 2004 to December 2014, and the literature involving cases were analyzed and discussed. Results Women with ADR induced by SSRI were more than men, and more were focused on 41 — 60 years old. Depression patients had the most ADR cases. In the varieties of SSRI, paroxetine had the highest ADR incidence. The most cases (30.5%) occured in the medication after 4 weeks. The cases of combination were 25, in which paroxetine had the most cases. ADR induced by SSRI mainly were nervous system (44.9%). Conclusion ADR induced by SSRI is common in clinic. The using of SSRI should be treated promptly, to ensure the medication safety.

國家自然科學(xué)基金資助項(xiàng)目(81403198)