目的 觀察補(bǔ)腎抗衰片治療腎虛痰瘀型2型糖尿病胰島素抵抗的臨床療效。方法 選取2013年7月—2014年9月在天津中醫(yī)藥大學(xué)第一附屬醫(yī)院就診的腎虛痰瘀型2型糖尿病胰島素抵抗患者80例, 隨機(jī)分為對(duì)照組和治療組, 每組40例。對(duì)照組給予常規(guī)治療方案。治療組在對(duì)照組治療基礎(chǔ)上口服補(bǔ)腎抗衰片, 6片/次, 3次/d。兩組均連續(xù)治療8周。觀察兩組患者的臨床療效, 同時(shí)比較兩組治療前后空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血紅蛋白(HbA1c)、空腹胰島素及胰島素抵抗指數(shù)(IRI)的變化。結(jié)果 治療后, 對(duì)照組和治療組總有效率分別為85.0%、97.5%, 兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.01)。治療后, 治療組FBG、2hPBG、HbA1c、空腹胰島素、IRI均明顯下降, 與同組治療前比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05), 且治療后治療組這些觀察指標(biāo)明顯低于對(duì)照組(P<0.05)。結(jié)論 補(bǔ)腎抗衰片治療腎虛痰瘀型2型糖尿病胰島素抵抗具有較好的臨床療效, 不僅能改善患者糖代謝, 還能增加胰島素敏感性, 改善胰島素抵抗, 為臨床治療腎虛痰瘀型2型糖尿病胰島素抵抗提供理論支持。

Objective To investigate the efficacy of Bushen Kangshuai Tablets in treatment of type 2 diabetes mellitus with insulin resistance of kidney deficiency and stagnant phlegm syndrome. Methods Patients (80 cases) with type 2 diabetes mellitus with insulin resistance of kidney deficiency and stagnant phlegm syndrome in First Affiliated Hospital of Tianjin University of TCM from July 2013 to September 2014 were randomly divided into control and treatment groups. Each group had 40 cases. Patients in control group were given conventional treatment. Patients in treatment group were po administered with Bushen Kangshuai Tablets on the basis of control group, 6 tablets/time, three times daily. Two groups were treated for 8 weeks. After treatment, the efficacy was evaluated, and the changes of FBG, 2hPBG, HbA1c, fasting insulin, and IRI in two groups were compared. Results The efficacies in the control and treatment groups were 85.0% and 97.5%, respectively, and there were differences between two groups (P < 0.05). After treatment, FBG, 2hPBG, HbA1c, fasting insulin and IRI in treatment group were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Bushen Kangshuai Tablets has the good clinical effect in treatment of type 2 diabetes mellitus with hyperlipidemia of kidney deficiency and stagnant phlegm syndrome, and not only can improve glucose metabolism, but also can increase insulin sensitivity, and can improve insulin resistance, which can provide theoretical support for clinical treatment of type 2 diabetes mellitus with insulin resistance of kidney deficiency and blood stasis syndrome.

國(guó)家自然科學(xué)基金面上項(xiàng)目(30973728)