目的 觀察荷丹片聯(lián)合瑞舒伐他汀治療2型糖尿病合并高脂血癥的臨床療效。方法 選擇2011年1月—2014年5月在天津市河北區(qū)建昌道街社區(qū)衛(wèi)生服務(wù)中心就診的2型糖尿病合并高脂血癥患者100例, 隨機分為對照組和治療組, 每組50例。對照組每日晚餐后口服瑞舒伐他汀鈣片10 mg/次, 1次/d。治療組在對照組治療的基礎(chǔ)上飯前30 min口服荷丹片, 2片/次, 3次/d。兩組均連續(xù)治療12周。觀察兩組的臨床療效, 同時比較兩組治療前后膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、空腹血糖(FPG)、餐后2 h血糖(2hPBG)以及糖化血紅蛋白(HbAlc)的變化。結(jié)果 治療后, 對照組和治療組的總有效率分別為82.0%、94.0%, 兩組總有效率比較差異有統(tǒng)計學意義(P<0.05)。治療后, 兩組患者的TG、TC、LDL-C、FPG、2hPG、HbAlc均較治療前顯著下降, HDL-C明顯升高, 同組治療前后差異有統(tǒng)計學意義(P<0.05);且治療后治療組這些觀察指標的改善程度優(yōu)于對照組, 兩組比較差異具有統(tǒng)計學意義(P<0.05)。結(jié)論 荷丹片聯(lián)合瑞舒伐他汀治療2型糖尿病合并高脂血癥具有較好的臨床療效, 可更好的調(diào)節(jié)血糖和血脂水平, 且安全性較好, 具有一定的臨床推廣應(yīng)用價值。

Objective To observe the clinical curative effect of Hedan Tablets combined with rosuvastatin in treatment of type 2 diabetes with hyperlipidemia. Methods Patients (100 cases) with type 2 diabetes with hyperlipidemia in Community Health Service Center of Tianjin Hebei District Jianchang Road from January 2011 to May 2014 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were po administered with Rosuvastatin Calcium Tablets after dinner, 10 mg/time, once daily. The patients in the treatment group were po administered with Hedan Tablets 30 min before meals on the basis of control group, 2 tablets/time, three times daily. Two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, and the changes of TC, TG, LDL-C, HDL-C, FPG, 2hPBG, and HbAlc in two groups were compared. Results The efficacies in the control and treatment groups were 82.0% and 94.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, TG, TC, LDL-C, FPG, 2hPG, and HbAlc in two groups were significantly reduced, while HDL-C were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Hedan Tablets combined with rosuvastatin has good clinical efficacy in treatment of type 2 diabetes with hyperlipidemia, and can regulate blood sugar and lipid levels with good safety, which has a certain clinical application value.