化療是食管癌治療的主要方法之一, 而多藥耐藥(MDR)現(xiàn)象是目前食管癌化療過程中遇到的最大障礙。腫瘤MDR是指腫瘤患者經(jīng)過某種化療藥物長期治療后, 除了對該化療藥物產(chǎn)生耐藥性, 對其他多種結(jié)構(gòu)和功能不同的抗腫瘤藥物亦產(chǎn)生耐藥。腫瘤MDR是一個多階段、多因素參與的復(fù)雜過程, 包括藥物轉(zhuǎn)運(yùn)蛋白的外排作用、靶酶的變化以及其他參與因素的改變等, 主要對食管癌多藥耐藥機(jī)制及其逆轉(zhuǎn)劑的研究進(jìn)展進(jìn)行綜述。

Chemotherapy is one of the main methods in treatment of esophageal carcinoma. However, multidrug resistance (MDR) is the greatest barrier during the chemotherapeutic process. MDR means that after treatment for a long period with some chemotherapeutic agents, patients resistant not only to this chemotherapeutic drug, but also to other structurally and functionally drugs. MDR is a complicated procedure involving multiple stages and multiple factors, including exocytosis of drug transporters, changes of target enzyme, and other involved factors. MDR mechanism of esophageal carcinoma and reversal agents are summarized in this brief review.