目的 對(duì)鹽酸維拉佐酮的合成工藝進(jìn)行研究.方法 以5-氰基吲哚為起始原料,通過傅克反應(yīng)、還原反應(yīng)、磺?；磻?yīng)、縮合反應(yīng)得到維拉佐酮,然后與鹽酸反應(yīng)得到鹽酸維拉佐酮.結(jié)果 合成了目標(biāo)化合物,并利用¹H-NMR、MS 確證了結(jié)構(gòu).此路線的總收率為47.89%,質(zhì)量分?jǐn)?shù)為99.66%.結(jié)論 該合成工藝設(shè)計(jì)合理,操作簡(jiǎn)單,適用于工業(yè)化生產(chǎn),鹽酸維拉佐酮的收率和純度較高.

Objective To study the synthetic technology of vilazodone hydrochloride. Methods 5-Cyanoindole was used as starting material to synthesize vilazodone by Friedel-Craft reaction, reduction reaction, sulfonylation reaction, and condensation reaction. Then vilazodone hydrochloride was synthesized by reacting with hydrochloric acid. Results The target compound was synthesized and characterized by ¹H-NMR and MS. The total yield of vilazodone hydrochloride with the purity of 99.66% was 47.89%. Conclusion The synthetic route of vilazodone hydrochloride has the advantages of reasonable design and simple operation with high yield and purity, and is suitable for industrial production.