目的 探討小兒智力糖漿聯(lián)合鹽酸哌甲酯片治療兒童注意缺陷多動(dòng)障礙的臨床療效.方法 選擇2012 年1 月-2014年12 月重慶市開縣人民醫(yī)院兒科收治兒童注意缺陷多動(dòng)障礙患者90 例,隨機(jī)分為對(duì)照組和治療組,每組45 例.對(duì)照組患者口服鹽酸哌甲酯片,2 片/次,1 次/d.治療組患者在對(duì)照組的治療基礎(chǔ)上口服小兒智力糖漿,10 mL/次,2 次/d.3 周為1個(gè)療程,全部患者均治療3 個(gè)療程.觀察兩組的臨床療效,同時(shí)比較兩組治療前后Conner 行為評(píng)定量表各因子評(píng)分及不良反應(yīng)情況.結(jié)果 治療后,對(duì)照組和治療組總有效率分別為77.78%、88.89%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05).治療后,兩組患者沖動(dòng)多動(dòng)、多動(dòng)指數(shù)、學(xué)習(xí)問題、品行問題、焦慮、身心問題評(píng)分均較較治療前顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P< 0.05);且治療組治療后各評(píng)分均顯著低于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05).兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計(jì)學(xué)意義.結(jié)論 小兒智力糖漿聯(lián)合鹽酸哌甲酯片治療兒童注意缺陷多動(dòng)障礙,能夠顯著提高臨床療效,且無嚴(yán)重不良反應(yīng),具有一定的臨床推廣價(jià)值.

Objective To investigate the clinical effect of Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets in treatment of attention deficit hyperactivity disorder. Methods Patients (90 cases) with attention deficit hyperactivity disorder in the derpartment of paediatrics of People's Hospital of Kaixian County in Chongqing from January 2012 to December 2014 were randomly divided into control and treatment groups. Each group had 45 cases. Patients in control group were po administered with Methylphenidate Hydrochloride Tablets, 2 tablets/time, once daily. Patients in treatment group were po administered with Xiaoer Zhili Syrup on the basis of the control group, 10 mL/time, twice daily. A course of treatment included 3 weeks, and the patients in two groups maintained the treatment for three coures. After treatment, the efficacy was evaluated, and the changes of each factor score in Conner behavior rating scale and adverse reactions in two groups before and after treatment were compared. Results The efficacies in the control and treatment groups were 77.78% and 88.89%, respectively, and there were differences between two groups (P < 0.05). After treatment, scores of impulse hyperactivity, index of hyperactivity, learning problems, character, anxiety, physical and mental problems in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in the treatment group improved better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Xiaoer Zhili Syrup combined with Methylphenidate Hydrochloride Tablets can significantly improve the clinical curative effect in treatment of attention deficit hyperactivity disorder with no serious adverse reaction, which has a certain clinical value.