目的 探討歐龍馬滴劑聯(lián)合阿奇霉素治療兒童慢性鼻竇炎的臨床療效.方法 選取2013 年7 月-2014 年6 月昆山市第一人民醫(yī)院收治的慢性鼻竇炎患兒131 例,隨機(jī)分為對(duì)照組(65 例)和治療組(66 例).對(duì)照組口服阿奇霉素顆粒5 mg/kg,1 次/d,同時(shí)使用鼻用激素,1 次/d.10 d 為1 個(gè)療程,第1～6 天用藥,第7～10 天停用.治療組在對(duì)照組的基礎(chǔ)上聯(lián)合應(yīng)用歐龍馬滴劑,1 個(gè)療程為10 d,第1～5 天,50 滴/次,第6～10 天,25 滴/次,3 次/d.兩組均連續(xù)治療9 個(gè)療程.觀察兩組的臨床療效,同時(shí)比較兩組治療前后鼻部癥狀、相關(guān)癥狀、睡眠障礙、情感結(jié)局、癥狀體征評(píng)分的變化.結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為87.69%、96.97%,兩組總有效率比較差異有統(tǒng)計(jì)學(xué)意義(P< 0.05).治療后,兩組患者鼻部癥狀、相關(guān)癥狀、睡眠障礙、情感結(jié)局、癥狀體征評(píng)分均較治療前顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P< 0.05);且治療組各觀察指標(biāo)的降低程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P< 0.05).結(jié)論 歐龍馬滴劑聯(lián)合阿奇霉素治療兒童慢性鼻竇炎具有較好的臨床療效,能明顯改善患兒的總體癥狀體征,改善鼻腔癥狀,具有一定的臨床推廣應(yīng)用價(jià)值.

Objective To investigate the clinical efficacy of Sinupret Drops combined with azithromycin in treatment of chronic sinusitis of children. Methods Patients (131 cases) with chronic sinusitis in the First People's Hospital of Kunshan from July 2013 to June 2014 were randomly divided into control (n=65) and treatment (n=66) groups. Patients in control group were po administered with Azithromycin Granules 5 mg/kg, once daily, and they were given nasal hormone, once daily. A period of treatment included 10 d, and the patients took drugs for 1-6 d, while 7-10 d was downtime. Patients in treatment group were given Sinupret Drops on the basis of control group, and a period of treatment included 10 d, 50 drops/time from day 1 to day 5, and 25 drops/time from day 6 to day 10, three times daily. Patients in two groups were treated for 9 courses. After treatment, the efficacy was evaluated, and the scores of nasal symptoms, associated symptoms, sleep disorders, emotional ending, signs and symptoms in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 87.69% and 96.97%, respectively, and there were differences between two groups (P < 0.05). The scores of nasal symptoms, associated symptoms, sleep disorders, emotional ending, signs and symptoms in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). The lower levels of those observation indexes improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Sinupret Drops combined with azithromycin has good effect in treatment of chronic sinusitis of children, and can obviously improve the patient's overall symptoms and signs, also can improve the nasal symptoms, which has a certain clinical application value.