目的 調(diào)查2013-2014 年河北北方學(xué)院附屬第一醫(yī)院住院抗菌藥物處方不合理用藥的情況,為促進(jìn)臨床合理應(yīng)用抗菌藥物提供依據(jù).方法 抽取2013 年1 月-2014 年12 月河北北方學(xué)院附屬第一醫(yī)院住院抗菌藥物處方20 000 張,對(duì)不合理用藥情況進(jìn)行回顧性分析.結(jié)果 抗菌藥物處方存在不合理用藥問題的共1 623 張,占8.12%;其中存在的問題主要為溶媒種類的選擇及溶媒量不當(dāng)、給藥劑量及給藥頻次不合理、療程過長(zhǎng)或偏短、聯(lián)合用藥指征不明確等;聯(lián)合用抗菌藥物品種數(shù)越多,不合理用藥的發(fā)生率越高;頭孢類和青霉素類使用率均較高,不合理用藥處方率分別為7.50%、6.19%;而使用率均較低的碳青霉烯類、頭霉素類以及抗真菌藥處方中不合理用藥處方率較高,分別為19.16%、18.36、19.17%.結(jié)論 河北北方學(xué)院附屬第一醫(yī)院住院患者抗菌藥物使用基本合理,但仍存在一些問題,需進(jìn)一步加強(qiáng)臨床醫(yī)師合理應(yīng)用抗菌藥物的相關(guān)培訓(xùn),并加大處方點(diǎn)評(píng)力度.

Objective To investigate the unreasonable antibiotic prescriptions in Inpatient Department of The First Affiliated Hospital of Hebei North University from 2013 to 2014, in order to provide a basis for promoting the clinical rational use of antibiotics. Methods By extracting 20 000 inpatient antibiotic prescriptions in The First Affiliated Hospital of Hebei North University from 2013 to 2014, the conditions of unreasonable use of antibiotics were recorded and investigated. Results There were 1 623 unreasonable antibiotic prescriptions which accounted for 8.12% of the samples. The main types of unreasonable medicine were improper choice of solvent, improper solvent amount, unreasonable dosage and frequency of drug administration, too long or short treatment, and unclear combination therapy indications. And the more the number of combined drugs, the higher the rate of unreasonable antibiotic prescriptions was. Cephalosporins and penicillins were used more often, but unreasonable prescription rates were 7.50% and 6.19%. while the unreasonable prescription rates of using carbapenem, cephamycin and antifungal antibiotics were relatively higher, which were 19.16%, 18.36%, and 19.17%, respectively. Conclusion The using of antibiotics in The First Affiliated Hospital of Hebei North University is basically rational, but there are still some problems, which need strengthening the training for clinicians to reasonable use of antibiotics, and strengthening prescription comment.