目的 分析天津市河北區(qū)鐵東路街社區(qū)衛(wèi)生服務中心抗高血壓藥物的應用情況和趨勢,為臨床合理用藥提供參考.方法 對2012-2014 年抗高血壓藥物的應用品種、銷售金額、用藥頻度(DDDs)及日均藥費(DDC)進行統(tǒng)計和分析.結果 2012-2014 年抗高血壓藥物的銷售金額呈逐年上升趨勢;該院抗高血壓藥物有鈣通道阻滯劑(CCB)、血管緊張素Ⅱ受體拮抗劑(ARB)、血管緊張素轉換酶抑制劑(ACEI)、β-受體阻滯劑(β-RB)、利尿藥及復方制劑;2012-2014 年銷售金額及構成比的排序均為CCB、ARB、ACEI、β-RB、利尿藥及復方制劑;CCB 中的硝苯地平在2012 年位居銷售金額及DDDs的首位;CCB 中的左旋氨氯地平在2013、2014 年位居銷售金額及DDDs 排序首位;ARB 中纈沙坦的DDC 在2012-2014年均為最高.結論 天津市河北區(qū)鐵東路街社區(qū)衛(wèi)生服務中心抗高血壓藥物以CCB、ARB、ACEI、β-RB 為主,應用基本合理,從用藥趨勢看CCB、ARB 具有良好的應用前景.

Objective To analyze the application and trend of antihypertensive drugs in Tiedong Road Community Health Service Center of Heibei District in Tianjin, to provide reference for clinical rational use. Methods The categories, consumption sum, defined daily doses (DDDs), and daily drug cost (DDC) of antihypertensive drugs were analyzed statistically. Results From 2012 to 2014, the consumption sum of antihypertensive drugs increased year by year. The antihypertensive drugs were calcium channel blockers (CCB), angiotensin Ⅱ receptor blockers (ARB), angiotensin converting enzyme inhibitors (ACEI), β-receptor blockers (β-RB), diuretics, and compound preparations. Sequences of consumption sum and constituent ratios from 2012 to 2014 were CCB, ARB, ACEI, β-RB, diureties, and compound preparations. Consumption sum and DDDs of nifedipine in CCB ranked the first in 2012. Consumption sum and DDDs of L-amlodipine in CCB ranked the first in 2013 and 2014. DDC of valsartan in ARB was the highest from 2012 to 2014. Conclusion The main antihypertensive drugs were CCB, ARB, ACEI, and β-RB in Tiedong Road Community Health Service Center of Heibei District in Tianjin. The application of antihypertensive drugs is basically rational. CCB and ARB have a good prospect of application from the trend of drug use.