目的 分析湛江中心人民醫(yī)院肺炎克雷伯菌耐藥性與抗菌藥物用量的相關(guān)性,為臨床合理用藥提供參考.方法 采用回顧性調(diào)查方法,統(tǒng)計(jì)湛江中心人民醫(yī)院2010-2014 年13 種抗菌藥物的用藥頻度(DDDs)及同期肺炎克雷伯菌的耐藥率,采用Pearson 法對(duì)肺炎克雷伯菌耐藥性與抗菌藥物用量的相關(guān)性進(jìn)行統(tǒng)計(jì)分析.結(jié)果 肺炎克雷伯菌對(duì)亞胺培南的耐藥率與亞胺培南用量呈顯著正相關(guān),與頭孢噻肟用量呈顯著負(fù)相關(guān);對(duì)莫西沙星的耐藥率與頭孢哌酮/舒巴坦、頭孢西丁用量呈顯著正相關(guān);對(duì)美羅培南的耐藥率與頭孢唑林、左氧氟沙星用量呈顯著負(fù)相關(guān)(P< 0.05).結(jié)論 肺炎克雷伯菌對(duì)抗菌藥物耐藥水平變化與抗菌藥物用量存在相關(guān)關(guān)系,臨床應(yīng)合理選用抗菌藥物,以減少或延緩耐藥菌株的產(chǎn)生.

Objective To analyze the correlation between drug resistance of Klebsiella pneumoniae and dose of antibiotics in Central People's Hospital of Zhanjiang, and to provide reference for rational drug use. Methods Defined daily doses (DDDs) of 13 antibiotics and drug resistance rate of K. pneumoniae in Central People's Hospital of Zhanjiang from 2010 to 2014 were reviewed, retrospectively. The correlation between drug resistance of K. pneumoniae and dose of antibiotics were analyzed by Pearson method. Results The resistance rate of K. pneumoniae against immipenam had positive correlation with the dose of immipenam, and negative correlation with the dose of cefotaxime. The resistance rate against moxifloxacin had positive correlation with the doses of cefoperazone/sulbactam and cefoxitin. The resistance rate against meropenem had negative correlation with the doses of cefozolin and levofloxacin, respectively (P < 0.05). Conclusions The resistance changes of K. pneumoniae have correlation with the doses of antibiotics. The proper choice of antibiotics could reduce or delay the development of antibiotic resistance.