人類免疫缺陷病毒(HIV)-1 侵入抑制劑能抑制HIV 進入靶細胞,在最初環(huán)節(jié)抑制病毒的傳播.具有高活性、較好藥物代謝性質的肽及肽類似物不斷被發(fā)現,并成為抗HIV 藥物研究的熱點.根據HIV-1 進入靶細胞的3 個步驟可將侵入抑制劑分為黏附抑制劑、輔助受體結合抑制劑和融合抑制劑,并對其研發(fā)策略和研究進展進行綜述.

Human immunodeficiency virus (HIV)-1 entry inhibitors can inhibit HIV entering the target cells, and restrain the spreading of virus at the first part. Peptide and peptide analogue with high activity, good metabolic characteristics continue to be discovered, and they become the research hot spot of anti-HIV drugs. According to three steps of HIV-1 into the target cells, HIV-1 entry inhibitors are divided into adhesion antagonists, auxiliary receptor inhibitors, and fusion inhibitors. Research strategies and recent insights of those peptides as well as their analogs are summarized.

黑龍江省教育廳科學技術研究項目(12521200);哈爾濱醫(yī)科大學藥學院大學生創(chuàng)新基金項目