目的 觀察舒眠膠囊聯(lián)合米氮平治療老年睡眠障礙的臨床療效。方法 選取2014年5月—2015年5月江油市人民醫(yī)院神經(jīng)內(nèi)科收治的睡眠障礙患者112例,隨機分為對照組和治療組,每組各56例。對照組每晚睡前口服米氮平片,1片/次,1次/d。治療組在對照組治療基礎(chǔ)上口服舒眠膠囊,3粒/次,2次/d。兩組患者均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組治療前后匹茲堡睡眠質(zhì)量指數(shù)(PSQI)、睡眠總時間、睡眠效率、睡眠潛伏期、快動眼(REM)潛伏期、夜間覺醒次數(shù)、覺醒總時間的變化。結(jié)果 治療后,對照組和治療組的總有效率分別為67.86%、89.29%,兩組總有效率比較差異具有統(tǒng)計學意義(P< 0.05)。治療后,兩組睡眠總時間、睡眠效率、REM潛伏期均顯著升高,PSQI評分、睡眠潛伏期、夜間覺醒次數(shù)、覺醒總時間均顯著下降,同組治療前后差異有統(tǒng)計學意義(P< 0.05);且治療組這些指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學意義(P< 0.05)。結(jié)論 舒眠膠囊聯(lián)合米氮平治療老年睡眠障礙具有較好的臨床療效,可改善患者的睡眠質(zhì)量,降低PSQI評分,具有一定的臨床推廣應用價值。

Objective To observe the clinical curative effect of Shumian Capsules combined with mirtazapine in treatment of elder sleep disorders. Methods Patients (112 cases) with elder sleep disorders in Department of Neurology of Jiangyou People's Hospital from May 2014 to May 2015 were randomly divided into control and treatment groups, and each group had 56 cases. The patients in the control group were po administered with Mirtazapine Tablets every night before going to bed, 1 tablet/time, once daily. The patients in the treatment group were po administered with Shumian Capsules on the basis of the control group, 3 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of PSQI, total sleep time, sleep efficiency, sleep latency, REM incubation period, night awakening times, and awakening total time in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 67.86% and 89.29%, respectively, and there were differences between two groups (P < 0.05). After treatment, total sleep time, sleep efficiency, and REM incubation period were significantly increased, and PSQI, sleep latency, night awakening times, and awakening total time were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Shumian Capsules combined with mirtazapine has clinical curative effect in treatment of elder sleep disorders, and can improve the sleep quality of patients and reduce the PSQI scores, which has a certain clinical application value.