目的 探討生血寧片聯(lián)合琥珀酸亞鐵片治療妊娠期缺鐵性貧血的臨床療效。方法 選擇2012年1月—2014年12月重慶市銅梁區(qū)中醫(yī)院收治的妊娠期缺鐵性貧血患者170例,隨機(jī)分為對照組和治療組,每組各85例。對照組患者在基礎(chǔ)治療的基礎(chǔ)上口服琥珀酸亞鐵片,2片/次,3次/d。治療組患者在對照組基礎(chǔ)上口服生血寧片,2片/次,3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組治療前后血清鐵(SI)、血紅蛋白(Hb)、紅細(xì)胞(RBC)、平均紅細(xì)胞體積(MCV)、平均紅細(xì)胞血紅蛋白濃度(MCHC)和鐵蛋白飽和度(TSAT)的變化。結(jié)果 治療后,對照組和治療組的總有效率分別為77.65%、88.24%,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05)。治療后,兩組患者Hb、RBC、MCV、MCHC、SI、TSAT水平均顯著高于治療前,同組治療前后差異均具有統(tǒng)計學(xué)意義(P< 0.05);治療后治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P< 0.05)。結(jié)論 生血寧片聯(lián)合琥珀酸亞鐵片治療妊娠期缺鐵性貧血臨床療效安全可靠,可顯著改善患者貧血癥狀和相關(guān)指標(biāo),且未見嚴(yán)重不良反應(yīng),具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical efficacy of Shengxuening Tablets combined with Ferrous Succinate Tablets in treatment of iron deficiency anemia during pregnancy. Methods Patients (170 cases) with iron deficiency anemia during pregnancy in Traditional Chinese Medicine Hospital. Tongliang, Chongqing from January 2012 to December 2014 were randomly divided into control and treatment groups, and each group had 85 cases. The patients in the control group were po administered with Ferrous Succinate Tablets on the basis of foundation treatment, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Shengxuening Tablets on the basis of the control group, 2 tablets/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacies in two groups were compared, and Hb, RBC, MCV, MCHC, TSAT, and SI in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 77.65% and 88.24%, respectively, and there were differences between two groups (P < 0.05). After treatment, Hb, RBC, MCV, MCHC, SI, and TSAT in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shengxuening Tablets combined with Ferrous Succinate Tablets has safe and reliable clinical curative effect in treatment of iron deficiency anemia during pregnancy, and can significantly improve the symptoms and indicators related to anemia, which has a certain clinical application value.