血脂異常是心血管疾病的一個高危因素,目前臨床上仍以藥物治療為主要手段。bempedoic acid是一種人工合成的、以口服為給藥途徑的二羧酸衍生物,其對肝臟三磷酸腺苷-檸檬酸裂解酶(ACL)和腺苷單磷酸-活化蛋白激酶(AMPK)有雙重調(diào)節(jié)作用,很有潛力成為另一個非他汀類的降脂藥。多項臨床試驗研究表明bempedoic acid具有良好的安全性和有效性。主要從bempedoic acid的藥物概況、相關(guān)背景、合成路線、作用機制和藥理作用、臨床研究等方面進(jìn)行介紹。

Dyslipidemia is a high risk factor for cardiovascular disease. Currently, pharmacologic therapy is still the main treatment in clinical. bempedoic acid is an oral synthetic dicarboxylic acid derivative. And it is a dual regulators of ACL and AMPK, and it has the potential to become another non-statins lipid-lowing drug. Many clinical studies show that bempedoic acid has a good safety and effectiveness. The drug situation, background, route of synthesis, mechanism and pharmacological action, and clinical trials researches of bempedoic acid are reviewed in this paper.