目的 探討益心舒膠囊聯(lián)合胺碘酮治療室性早搏的臨床療效。方法 選擇2014年6月—2015年1月徐州市中心醫(yī)院收治的室性早搏患者104例,按照治療方法分為對(duì)照組(48例)和治療組(56例)。對(duì)照組口服鹽酸胺碘酮片,0.2 g/次,第1周3次/d,第2周2次/d,第3、4周1次/d。治療組在對(duì)照組治療的基礎(chǔ)上口服益心舒膠囊,3粒/次,3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效、室性早搏療效和心電圖療效,同時(shí)比較兩組治療前后臨床癥狀評(píng)分的變化。結(jié)果 治療后,對(duì)照組和治療組的臨床療效總有效率分別為83.33%、96.43%,室性早搏總有效率分別為72.92%、89.29%,心電圖總有效率分別為77.08%、91.07%,兩組比較差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組心悸不安、乏力氣短、胸悶胸痛的癥狀評(píng)分均較治療前顯著下降,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 益心舒膠囊聯(lián)合胺碘酮治療室性早搏的臨床療效確切,可顯著改善臨床癥狀,且不良反應(yīng)較小,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Yixinshu Capsules combined with amiodarone in treatment of ventricular premature beat. Methods Patients (104 cases) with premature ventricular were enrolled in this study from June 2014 to January 2015. According to the different treatment plan, patients were divided into treatment group (56 cases) and control group (48 cases). The patients in the control group were po administered with Amiodarone Hydrochloride Tablets, 0.2 g/time, three times daily in the first week, twice daily in the second week, once daily in the third and fourth week. The patients in the treatment group were po administered with Yixinshu Capsules on the basis of control group, 3 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy, ventricular premature beat efficacies, and electrocardiogram efficacies were evaluated; And the changes of clinical symptom scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 83.33% and 96.43%, respectively, and ventricular premature beat efficacies in two groups were 72.92% and 89.29%, electrocardiogram efficacies in two groups were 77.08% and 91.07%, and there were differences between two groups (P < 0.05). The symptom scores of heart palpitations, weakness, shortness of breath, and chest tightness of chest pain in two groups were significantly reduced; And the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Yixinshu Capsules combined with amiodarone has clinical curative effect in treatment of ventricular premature beat, and can significantly improve the clinical symptoms with less adverse reaction, which has a certain clinical application value.