目的 觀察維生素AD滴劑聯(lián)合孟魯司特鈉咀嚼片治療毛細(xì)支氣管炎的臨床療效。方法 選擇衡水市桃城區(qū)婦幼保健院2015年1月—2015年6月確診的毛細(xì)支氣管炎患兒80例,隨機(jī)分為對(duì)照組(40例)和治療組(40例)。對(duì)照組口服孟魯司特鈉咀嚼片,6個(gè)月以下患兒2 mg/次,6個(gè)月以上患兒4 mg/次,每晚1次。治療組在對(duì)照組的基礎(chǔ)上加用維生素AD滴劑,1粒/次,1次/d。兩組患兒均連續(xù)用藥7 d。觀察兩組患兒治療后的臨床療效和臨床癥狀,比較γ-干擾素(IFN-γ)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為87.5%、95.0%,兩組患兒總有效率比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后治療組患兒氣促、咳嗽、喘憋、肺部體征消失時(shí)間和呼吸、心率恢復(fù)正常時(shí)間與對(duì)照組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組IFN-γ水平顯著升高,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組的上升程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 維生素AD滴劑聯(lián)合孟魯司特鈉治療毛細(xì)支氣管炎具有較好的臨床療效,可明顯減輕臨床癥狀和體征,不良反應(yīng)較少,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical efficacy of Vitamin A and D Drops combined with Montelukast Sodium Chewable Tablets in treatment of capillary bronchitis. Methods Children (80 cases) with capillary bronchitis in Maternity and Child Health Hospital of Hengshui City Taocheng District from January 2015 to June 2015 were randomly divided into control and treatment groups, and each group had 40 cases. Children in control group were po administered with Montelukast Sodium Chewable Tablets, once daily at night. The amounts of drugs were corresponding with ages of children, such as below six months children had 2 mg/ time, but above six months children had 4 mg/ time. Children in treatment group were added Vitamin A and D Drops on the basis of control group, 1 grain/time, once daily. The children in two groups were treated for 7 d. The clinical efficacies and symptoms of the two groups were observed, and the levels of γ-interferon (IFN-γ), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were compared between two groups. Results After treatment, the efficacies in the control and treatment groups were 87.5% and 95.0%, respectively, and there were significant differences between two groups (P < 0.05). After treatment, disappear time of breath, cough, wheezing, and pulmonary symptoms, and returned to normal time of respiration and heart rate in treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, level of IFN-γ was obviously increased, and the difference was statistically significant in the same group (P < 0.05). The observational index in the treatment group was better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Vitamin A and D Drops combined with Montelukast Sodium Chewable Tablets has clinical curative effect in treatment of capillary bronchitis, can significantly reduce the clinical symptoms and signs, and less adverse reactions, which has a certain clinical application value.