目的 觀察氨氯地平聯(lián)合硫酸鎂治療妊娠期高血壓的臨床療效。方法 選取2012年4月—2015年6月福建省龍巖市第二醫(yī)院收治的妊娠期高血壓患者100例,隨機分為對照組和治療組,每組各50例。對照組靜脈滴注硫酸鎂注射液20 mL加入到5%葡萄糖溶液100 mL,0.5 h內(nèi)滴注完畢,繼而以硫酸鎂注射液60 mL加入5%葡萄糖溶液1 000 mL中靜脈滴注9 h。治療組在對照組的治療基礎(chǔ)上加用苯磺酸氨氯地平片,10 mg/次,1次/d。兩組患者持續(xù)服藥,血壓降到治療目標(biāo)且穩(wěn)定后要對患者持續(xù)治療,直到妊娠結(jié)束。觀察兩組的臨床療效和妊娠結(jié)局,觀察兩組治療前后的血壓變化。結(jié)果 治療后,對照組和治療組的總有效率分別為68.0%、90.0%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組收縮壓和舒張壓均顯著降低,同組治療前后差異有統(tǒng)計學(xué)意義(P<0.05);治療后治療組的下降程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療組在產(chǎn)后出血、早產(chǎn)、胎盤早剝、新生兒呼吸窘迫、新生兒死亡方面均低于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 氨氯地平聯(lián)合硫酸鎂治療妊娠期高血壓療效較好,可顯著降低患者的血壓,改善妊娠結(jié)局,具有一定的臨床推廣應(yīng)用價值。

Objective To observe the clinical effect of amlodipine combined with magnesium sulfate in treatment of gestational hypertension. Methods Patients (100 cases) with gestational hypertension in the Second Hospital of Longyan from April 2012 to June 2015 were randomly divided into control and treatment groups, and each group had 50 cases. The patients in the control group were iv administered with Magnesium Sulfate Injection, 20 mL Magnesium Sulfate Injection added into 5% glucose solution 100 mL, which finished within 0.5 h. And then they were iv administered with Magnesium Sulfate Injection 60 mL added into 5% glucose solution 1000 mL in 9 h. The patients in treatment group were po administered with Amlodipine Besylate Tablets, 10 mg/time, once daily. When blood pressure descended to the target, patients in two groups were accepted continuous treatment until the end of the pregnancy. After treatment, the efficacy and pregnancy outcomes were evaluated, and the changes of blood pressure in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 68.0% and 90.0%, respectively, and there were differences between two groups (P < 0.05). After treatment, systolic and diastolic blood pressures in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P < 0.05). The incidence of postpartum hemorrhage, premature labor, placental abruption, neonatal respiratory distress, and neonatal death were lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Amlodipine combined with magnesium sulfate has clinical curative effect in treatment of gestational hypertension, and can significantly reduce the blood pressure, also can improve the pregnancy outcome, which has a certain clinical application value.