目的 分析2012—2014年天津市腫瘤醫(yī)院鎮(zhèn)痛藥物的使用情況,為臨床合理使用鎮(zhèn)痛藥物提供依據。方法 調取2012—2014年天津市腫瘤醫(yī)院鎮(zhèn)痛藥物的相關信息,對藥物劑型、銷售金額、用藥頻度(DDDs)、日均費用(DDC)及藥品排序比(B/A)進行統計分析。結果 2012—2014年鎮(zhèn)痛藥物的銷售金額逐年增加,速釋口服劑型及緩、控釋制劑構成比遠超注射劑,達到97%以上。各品種鎮(zhèn)痛藥物的DDDs變化較大但排序基本穩(wěn)定,鹽酸布桂嗪注射液、氨酚羥考酮片及芬太尼透皮貼劑的DDDs值分別位居各劑型的首位。大部分鎮(zhèn)痛藥物的DDC值各年份略有差異,15種藥品的DDC值小于100,患者負擔較輕。75%鎮(zhèn)痛藥物的B/A值接近于1,表明用藥同步性較好。結論 天津市腫瘤醫(yī)院鎮(zhèn)痛藥品的使用日趨合理,但也存在個別藥品日均費用較高、同步性較差的問題,需進一步加強管理。

Objective To analyze the utilization of analgesic drugs in Tianjin Cancer Hospital from 2012 to 2014, and to provide reference for rational use of drugs in clinic. Methods The utilization information of analgesic drugs in Tianjin Cancer Hospital from 2012 to 2014 was extracted, and the dosage form of drugs, consumption sum, defined daily doses (DDDs), defined daily cost (DDC) and drug sequence ratio (B/A) were analyzed statistically. Results From 2012 to 2014, the consumption sum of analgesic drugs was increasing year by year, and the constituent ratios of fast-release tablets and sustained release preparation were above 97% far exceeding that of the injection. DDDs of analgesic drugs changed obviously, but the sequences were stable. DDDs of Bucinnazine Hydrochloride Injection, Oxycodone-acetaminophen Tablets and Fentanyl Transdermal System ranked the first in three dosage forms, respectively. DDC of most analgesic drugs had subtle difference, and DDC of 15 drugs were less than 100, which resulted minor economic burden for cancer patient. B/A of 75% analgesic drugs closed to 1.00, indicating that the synchronism was better. Conclusion The utilization of analgesic drugs in Tianjin Cancer Hospital is gradually reasonable. However, the problem of high average daily cost and poor synchronism of few drugs are still existed, which needs further efforts to strengthen the management.