目的 探究谷紅注射液聯(lián)合鹽酸法舒地爾注射液治療缺血性腦梗死的臨床療效。方法 選取遵義醫(yī)學(xué)院附屬醫(yī)院2013年5月-2015年5月收治的缺血性腦梗死患者78例,根據(jù)治療方案的不同分為對照組和治療組,每組各39例。所有患者均給予降低顱內(nèi)壓、營養(yǎng)神經(jīng)、調(diào)節(jié)血脂等基礎(chǔ)治療。對照組靜脈滴注鹽酸法舒地爾注射液,60 mg加入250 mL生理鹽水中,1次/d。治療組在對照組基礎(chǔ)上靜脈滴注谷紅注射液,20 mL加入150 mL生理鹽水中,1次/d。兩組患者治療14 d。觀察兩組的臨床療效,比較兩組治療前后血液流變學(xué)、內(nèi)皮素-1(ET-1)和神經(jīng)功能缺損量表(NIHSS)評分的變化。結(jié)果 治療后,對照組和治療組總有效率分別為79.49%、87.18%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者紅細(xì)胞沉降率(ESR)、血細(xì)胞比容(HCT)、纖維蛋白原(FIB)、紅細(xì)胞聚集指數(shù)(RF)、全血高切黏度(HBV)均較治療前下降,同組治療前后差異具有統(tǒng)計學(xué)意義(P<0.05);治療組ESR、HCT、RF以及HBV的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者NIHSS評分及ET-1均較治療前顯著下降,同組治療前后差異具有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 谷紅注射液聯(lián)合鹽酸法舒地爾注射液治療缺血性腦梗死具有較好的臨床效果,能夠明顯改善患者的血液流變學(xué)狀態(tài),并能顯著降低ET-1,具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical effect of Guhong Injection combined with Fasudil Hydrochloride Injection in treatment of ischemic cerebral infarction. Methods Patients (78 patients) with ischemic cerebral infarction in Affiliated Hospital of Zunyi Medical College from May 2013 to May 2015 were divided into control and treatment groups according to the different treatment plans, and each group had 39 cases. All patients were given conventional basic treatment with reducing intracranial pressure, trophic nerve, and lipid regulating. Patients in the control group were iv administered with Fasudil Hydrochloride Injection, 60 mg added into 250 mL normal saline, once daily. Patients in the treatment group were iv administered with Guhong Injection, 20 mL added into 150 mL normal saline, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of hemorheology, ET-1, and NIHSS score in the two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 87.18%, respectively, and there were differences between two groups (P < 0.05). After treatment, ESR, HCT, FIB, RF, and HBV in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And ESR, HCT, RF, and HBV in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, NIHSS scores and ET-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Guhong Injection combined with Fasudil Hydrochloride Injection has clinical curative effect in treatment of ischemic cerebral infarction, and can significantly improve hemorheology, and can significantly reduce ET-1, which has a certain clinical application value.