目的 研究糖脈康顆粒聯(lián)合甲鈷胺注射液和α-硫辛酸注射液治療糖尿病周圍神經(jīng)病變的臨床療效。方法 選取2014年6月-2015年6月成都新華醫(yī)院收治的糖尿病周圍神經(jīng)病變患者170例,按照隨機(jī)數(shù)字表法將患者分為治療組和對照組,每組各85例。所有患者均給予飲食、運(yùn)動治療、口服降糖藥或者胰島素基礎(chǔ)治療。在此基礎(chǔ)治療上,對照組肌肉注射甲鈷胺注射液,0.5 mg/次,2天1次;靜脈滴注α-硫辛酸注射液,600 mg加入到250 mL生理鹽水中,1次/d。治療組在對照組的基礎(chǔ)上給予糖脈康顆粒,1袋/次,3次/d。兩組患者均持續(xù)治療1個(gè)月。觀察兩組患者臨床療效,比較治療前后總膽固醇(TC)、糖化血紅蛋白(HbA1c)、血尿素氮(BUN)及神經(jīng)傳導(dǎo)速度的變化。結(jié)果 治療后,對照組和治療組總有效率分別為70.6%、90.6%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者TC、HbA1c及BUN均顯著降低,同組治療前后差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者神經(jīng)傳導(dǎo)速度顯著增加,同組治療前后差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組神經(jīng)傳導(dǎo)速度增加明顯高于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 糖脈康顆粒聯(lián)合甲鈷胺注射液和α-硫辛酸注射液治療糖尿病周圍神經(jīng)病變的臨床療效較好,可改善糖代謝和脂代謝情況,增加神經(jīng)傳導(dǎo)速度,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To study the clinical effect of Tangmaikang Granules combined with Mecobalamin Injection and α-Lipoic Acid Injection in treatment of diabetic peripheral neuropathy. Methods Patients (170 cases) with diabetic peripheral neuropathy in Chendu Xinhua Hospital from June 2014 to June 2015 were divided into control and treatment groups according to the random number table, and each group had 85 cases. All patients were given conventional basic treatment with diet, exercise, oral hypoglycemic drugs, and insulin. The patients in the control group was im administered with Mecobalamin Injectionm, 0.5 mg/time, once every other day. They were also iv administered with α-Lipoic Acid Injection, 600 mg added into 250 mL of normal saline, once daily. The patients in the treatment group were given Tangmaikang Granules, 1 bag/time, three times daily. The patients in two groups were treated for 1 month. The clinical efficacies in two groups were observed, and the changes of total cholesterol (TC), glycosylated hemoglobin (HbA1c), blood urea nitrogen (BUN), and nerve conduction velocity were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 70.6% and 90.6%, respectively, and there was difference between groups (P < 0.05). After treatment, TC, HbA1c, and BUN in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). The observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, nerve conduction velocity in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And nerve conduction velocity in the treatment group was significantly better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Tangmaikang Granules combined with Mecobalamin Injection and α-Lipoic Acid Injection has clinical curative effect in treatment of diabetic peripheral neuropathy, and can improve glucose metabolism and lipid metabolism, and increase nerve conduction velocity, which has a certain clinical application value.