目的 探討海昆腎喜膠囊聯(lián)合阿魏酸鈉治療慢性腎衰竭的臨床療效。方法 選取2012年5月-2015年5月彭州市中醫(yī)醫(yī)院收治的慢性腎衰竭患者120例,隨機分為對照組和治療組,每組各60例。對照組靜脈滴注注射用阿魏酸鈉,0.3 g加入到5%葡萄糖注射液200 mL中,1次/d。治療組在對照組的基礎(chǔ)上口服海昆腎喜膠囊,2粒/次,3次/d。兩組均連續(xù)治療4周。觀察兩組的臨床療效,同時比較兩組治療前后血清尿素氮、血肌酐、內(nèi)生肌酐清除率及尿蛋白的變化情況。結(jié)果 治療后,對照組和治療組的總有效率分別為71.67%、81.67%,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療后,兩組患者血清尿素氮、血肌酐、尿蛋白均顯著降低,內(nèi)生肌酐清除率顯著升高,同組治療前后差異具有統(tǒng)計學(xué)意義(P<0.05);治療組這些觀察指標的改善程度優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 海昆腎喜膠囊聯(lián)合阿魏酸鈉治療慢性腎衰竭具有較好的臨床療效,可降低患者血清尿素氮、血肌酐及尿蛋白,提高內(nèi)生肌酐清除率,具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Haikun Shenxi Capsules combined with sodium ferulate in treatment of chronic renal failure. Methods Patients (120 cases) with chronic renal failure in Pengzhou Hospital of Traditional Chinese Medicine from May 2012 to May 2015 were randomly divided into control (n=60) and treatment (n=60) groups. The patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g add into 5% glucose injection 200 mL, once daily. The patients in the treatment group were po administered with Haikun Shenxi Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of serum urea nitrogen, serum creatinine, endogenous creatinine clearance and urinary protein in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 71.67% and 81.67%, respectively, and there were differences between two groups (P < 0.05). After treatment, serum urea nitrogen, serum creatinine, and urine protein were significantly decreased, and endogenous creatinine clearance were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Haikun Shenxi Capsules combined with sodium ferulate has clinical curative effect in treatment of chronic renal failure, and can reduce serum urea nitrogen, serum creatinine and urinary protein, also can improve the endogenous creatinine clearance, which has a certain clinical application value.