目的 探討丹紅注射液聯(lián)合血必凈注射液治療嚴(yán)重膿毒癥的臨床療效。方法 收集2011年2月-2015年6月天津中醫(yī)藥大學(xué)第二附屬醫(yī)院收治的嚴(yán)重膿毒癥患者80例,隨機(jī)分為對(duì)照組和治療組,每組各40例。對(duì)照組靜脈滴注血必凈注射液,50 mL加入100 mL生理鹽水中,2次/d。治療組在對(duì)照組治療的基礎(chǔ)上靜脈滴注丹紅注射液,20 mL加入5%葡萄糖注射液250 mL,1次/d。兩組均連續(xù)治療7 d。觀察治療前后兩組患者體溫(T)、心率(HR)、呼吸頻率(R)、APACHEⅡ評(píng)分、白細(xì)胞數(shù)(WBC)、腫瘤壞死因子-α(TNF-α)、白細(xì)胞介素-6(IL-6)、白細(xì)胞介素-10(IL-10)、C反應(yīng)蛋白(CRP)、降鈣素原(PCT)、丙氨酸氨基轉(zhuǎn)移酶(ALT)、天冬氨酸氨基轉(zhuǎn)移酶(AST)、尿素氮(BUN)、肌酐(Cr)、磷酸激酶同工酶(CPK)的變化及兩組患者治療7 d的病死率。結(jié)果 治療后,兩組患者T、HR、R、APACHEⅡ評(píng)分、WBC、TNF-α、IL-6、IL-10、CRP、PCT、ALT、AST、BUN、Cr和CPK均顯著降低,同組治療前后差異具有統(tǒng)計(jì)學(xué)意義(P<0.05);但治療組降低的程度更明顯,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,對(duì)照組和治療組的病死率分別為40.0%、27.5%,兩組病死率比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 丹紅注射液聯(lián)合血必凈注射液治療嚴(yán)重膿毒癥臨床療效顯著,能明顯改善患者的各項(xiàng)生命指標(biāo)、炎癥指標(biāo)及生化指標(biāo),具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore the clinical effect of Danhong Injection combined with Xuebijing Injection in treatment of severe sepsis. Methods Patients (80 cases) with severe sepsis in Department of Emergency of Second Affiliated Hospital of Tianjin University of TCM from February 2011 to June 2015 were randomly divided into control (n=40) and treatment (n=40) groups. The patients in the control group were iv administered with Xuebijing Injection, 50 mL added into normal saline 100 mL, twice daily. The patients in the treatment group were iv administered with Xuebijing Injection on the basis of the control group, 20 mL added into 5% glucose injection 250 mL, once daily. The patients in two groups were treated for 7 d. After treatment, the changes of T, HR, R, APACHEⅡ scores, WBC, TNF-α, IL-6, IL-10, CRP, PCT, ALT, AST, BUN, Cr, and CPK in two groups before and after treatment were compared, and fatality rates in 7 d of the treatment in two groups were compared. Results After treatment, T, HR, R, APACHEⅡ scores, WBC, TNF-α, IL-6, IL-10, CRP, PCT, ALT, AST, BUN, Cr and CPK in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the fatality rates in the control and treatment groups were 40.0% and 27.5%, respectively, and there were differences between two groups (P < 0.05). Conclusion Danhong Injection combined with Xuebijing Injection has clinical curative effect in treatment of severe sepsis, and can obviously improve the life indicators, inflammation indexes and biochemical indexes, which has a certain clinical application value.