目的 觀察孟魯斯特鈉聯(lián)合布地奈德和復(fù)方異丙托溴銨治療嬰幼兒毛細(xì)支氣管炎的臨床療效。方法 選取2014年1-12月遂川縣婦幼保健院收治的毛細(xì)支氣管炎患兒120例,分為對(duì)照組和治療組,每組各60例。對(duì)照組在常規(guī)治療基礎(chǔ)上霧化吸入用布地奈德混懸液0.5 mg和吸入用復(fù)方異丙托溴銨溶液1.25 mL,用生理鹽水稀釋到2 mL,2次/d;治療組在對(duì)照組的基礎(chǔ)上口服孟魯司特鈉咀嚼片,6個(gè)月以下患兒2 mg/次,6個(gè)月~1歲患兒3 mg/次,每晚1次。療程至癥狀和體征消失后一周。觀察兩組患兒治療后的臨床療效和臨床癥狀。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為85.0%、98.3%,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療組患兒的呼吸困難、氣喘、喘鳴音、濕性羅音、咳嗽消失時(shí)間及住院時(shí)間均比對(duì)照組縮短,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 孟魯斯特鈉聯(lián)合布地奈德和復(fù)方異丙托溴銨治療嬰幼兒毛細(xì)支氣管炎療效顯著,能迅速改善患兒的臨床癥狀,不良反應(yīng)較少,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the curative effect of montelukast sodium combined with budesonide and compound ipratropium bromide in treatment of infants with capillary bronchitis. Methods Infants (120 cases) with capillary bronchitis in Suichuan County Maternal and Child Health Hospital from January 2014 to December 2014 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in control group were aerosol inhalation administered with Budesonide Suspension for inhalation 0.5 mg and Compound Ipratropium Bromide Solution for inhalation 1.25 mL, diluted to 2 mL with 0.9% normal saline on the basis of conventional treatment, twice daily. Patients in treatment group were po administered with Montelukast Sodium Chewable Tablets on the basis of control group once daily at night. The amounts of drugs were corresponding with ages of children, such as below six months children had 2 mg/time, but six months to one years old children had 3 mg/time. The two groups were treated until symptoms and signs disappeared for one week. After treatment, the efficacy and disappeared time of dyspnea, asthma, wheezing rales, moist rales, and cough were evaluated. Results After treatment, the efficacies in the control and treatment groups were 85.0% and 98.3%, respectively, and there were significant differences between two groups (P < 0.05). After treatment, disappear time of dyspnea, asthma, wheezing rales, moist rales, and cough were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Montelukast sodium combined with budesonide and compound ipratropium bromide has good effect in treatment of infants with capillary bronchitis, and can improve clinical symptoms rapidly, and less adverse reactions, which has a certain clinical application value.