目的 了解南京地區(qū)34家醫(yī)院2012-2014年抗真菌藥物的使用情況和趨勢,為臨床合理用藥提供參考。方法 收集2012-2014年南京地區(qū)34家醫(yī)院抗真菌藥物的使用數(shù)據(jù),對(duì)抗真菌藥物的銷售金額、用藥頻度(DDDs)等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 2012-2014年南京地區(qū)34家醫(yī)院抗真菌藥物的總銷售金額及構(gòu)成比逐年上升。深部抗真菌藥的用藥金額遠(yuǎn)大于淺部抗真菌藥,其中三唑類用藥金額最大,其次是棘白菌素類?？拐婢幗痤~排序中三唑類藥物排在前列,伏立康唑和氟康唑穩(wěn)居第1、2位。淺表抗真菌藥以特比萘芬為主,銷售金額逐年下降?？拐婢幍腄DDs排序中,深部抗真菌藥中三唑類伊曲康唑排在前列,淺部抗真菌藥克霉唑、硝呋太爾制霉素排名也居于前列。結(jié)論 南京地區(qū)醫(yī)院2012-2014年抗真菌藥物的用藥金額呈增長趨勢,應(yīng)加強(qiáng)對(duì)抗真菌藥物的臨床應(yīng)用評(píng)價(jià)工作,從而促進(jìn)抗真菌藥的臨床合理應(yīng)用。

Objective To investigate the use and trend of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014, and to provide reference for reasonable application of antifungal drugs. Methods The data of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014 were collected, sales amount, consumption sum, and the frequency of drug use (DDDs) were analyzed statistically. Results The total consumption sum and constituent ratio of antifungal drugs in 34 hospitals from Nanjing area during 2012-2014 increased yearly. Consumption sum of deep antifungal drugs were more than those of superficial antifungal drugs. The consumption sum of triazoles was the largest, and the next were echinocandins. In the consumption sum sequence of antifungal drugs, voriconazole and fluconazole in triazoles ranked the first and second. Superficial antifungal drugs were mainly consisted of terbinafine, while the consumption sum of that decreased yearly. In DDDs sequence of antifungal drugs, itraconazole in triazoles of antifungal drugs was ranked the first. In superficial antifungal drugs, clotrimazole and nifuratel nysfungin ranked the top. Conclusion The consumption sum of hospitals from Nanjing area has a tendency to increase. Therefore, clinical evaluation of antifungal drugs should be strengthened, and to promote reasonable application of antifungal drugs in clinic.

江蘇高校優(yōu)勢學(xué)科建設(shè)工程資助項(xiàng)目