在細(xì)胞與細(xì)胞之間,橋粒提供一種強(qiáng)大的黏附作用,將細(xì)胞與中間纖維骨架相連,使細(xì)胞間的連接更為牢固。橋粒鈣黏蛋白是一種Ca²⁺依賴型的黏附蛋白,主要存在于橋粒中,并且是構(gòu)成橋粒的重要組成部分。橋粒鈣黏蛋白與一些皮膚性疾病息息相關(guān),它能參與黏附并維持組織結(jié)構(gòu)的完整性,一旦橋粒鈣黏蛋白的表達(dá)下降使組織間黏附喪失,將會(huì)導(dǎo)致一些皮膚性疾病如天皰瘡、水皰性膿皰病和葡萄球菌性燙傷樣皮膚綜合癥等的發(fā)生。橋粒鈣黏蛋白家族成員具有多樣性且各種蛋白在組織不同部位的表達(dá)具有復(fù)雜性,將對(duì)橋粒鈣黏蛋白家族的成員及其在皮膚疾病方面的性質(zhì)和功能作一個(gè)較全面的綜述。

Desmosomes provide a strong adhesion between the cells, and they link intracellularly to the intermediate filament cytoskeleton to make the junction more strong. The desmosomal cadherins are Ca²⁺-dependent adhesion proteins and exist in desmosomes, and are the important parts of desmosomes. The desmosomal cadherins are closely related to some skin diseases. They are involved in adhension and can maintain the integrity of the organizational structures. When the expression decrease of desmosomal cadherins results in adhesion fails, some skin disease such as pemphigus, bullous impetigo, and staphylococcal scalded skin syndrome, etc will occur. The family members of desmosomal cadherins have diversity and the expression in different parts of the tissues is complex. Therefore, this article will review the family members of desmosomal cadherins, and their properties and function in skin diseases.

國(guó)家重大新藥創(chuàng)制科技重大專項(xiàng)(2012ZX09101202)