目的 探究致康膠囊聯(lián)合蘭索拉唑治療十二指腸潰瘍出血的療效觀察。方法 選取2012年4月-2015年4月內(nèi)江市第二人民醫(yī)院收治的十二指腸潰瘍出血患者98例,按治療方案不同分為對照組和治療組,每組各49例。對照組靜脈滴注注射用蘭索拉唑,30mg溶于100mL0.9%氯化鈉溶液中,1次/d。治療組在對照組基礎(chǔ)上口服致康膠囊,2粒/次,3次/d。兩組患者均治療14d。觀察兩組的臨床療效,同時比較兩組患者止血效果、腹痛消失時間及不良反應(yīng)情況。結(jié)果 治療后,對照組和治療組的總有效率分別為81.63%、95.92%,兩組比較差異有統(tǒng)計學意義(P<0.05)。治療后,對照組和治療組的72h止血率分別為75.51%、91.84%,兩組比較差異有統(tǒng)計學意義(P<0.05)。治療組止血時間和腹痛消失時間均比對照組縮短,兩組比較差異有統(tǒng)計學意義(P<0.05)。對照組和治療組的不良反應(yīng)發(fā)生率分別為8.16%、6.12%,兩組比較差異無統(tǒng)計學意義。結(jié)論 致康膠囊聯(lián)合蘭索拉唑治療十二指腸潰瘍出血具有較好的臨床療效,能縮短止血時間,不良反應(yīng)少,具有一定的臨床推廣應(yīng)用價值。

Objective To explore the clinical efficacy of Zhikang Capsules combined with lansoprazol in treatment of duodenal ulcer bleeding. Methods Patients (98 cases) with duodenal ulcer bleeding in the Second People's Hospital of Neijiang from April 2012 to April 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control and treatment groups, and each group had 49 cases. The patients in the control group were iv administered with Lansoprazole for Injection, 30 mg added into 100 mL normal saline, once daily. The patients in the treatment group were po administered with Zhikang Capsules on the basis of control group, 2 grains/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies in two groups were evaluated, and the hemostatic effect, abdominal pain disappearance time, and adverse reaction in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.63% and 95.92%, respectively, and there was difference between two groups (P < 0.05). After treatment, the 72 h hemostatic rate in the control and treatment groups were 75.51% and 91.84%, respectively, and there was difference between two groups (P < 0.05). The hemostatic time and abdominal pain disappearance time in the treatment group were shorter than those in the control group, and there were differences between two groups (P < 0.05). The incidence of adverse reactions in the control and treatment groups were 8.16% and 6.12%, respectively, and there was no difference between two groups. Conclusion Zhikang Capsules combined with lansoprazole has clinical curative effect in treatment of duodenal ulcer bleeding, and can shorten hemostatic time, lessen adverse reactions, which has a certain clinical application value.