目的 探討腫痛安膠囊聯(lián)合鹽酸米諾環(huán)素治療智齒冠周炎的臨床療效。方法 選取2015年1月-2016年1月上海市奉賢區(qū)奉城醫(yī)院收治的智齒冠周炎患者106例,隨機分為對照組和治療組,每組各53例。對照組給予鹽酸米諾環(huán)素軟膏,置入牙周袋中,直至部分溢出為止,1次/d。治療組在對照組治療的基礎上口服腫痛安膠囊,2粒/次,3次/d。兩組患者均連續(xù)治療5d。觀察兩組的臨床療效,同時比較兩組治療前后革蘭氏染色情況、牙齦指數(shù)(GI)、疼痛緩解情況。結果 治療后,對照組和治療組的總有效率分別為84.91%、96.23%,兩組比較差異具有統(tǒng)計學意義(P<0.05)。治療后,兩組患者細菌密度、螺旋體、G^-菌、GI均顯著降低,G⁺菌顯著升高,同組治療前后差異具有統(tǒng)計學意義(P<0.05);且與對照組相比,治療組這些指標的改善程度更顯著,兩組比較差異有統(tǒng)計學意義(P<0.05)。治療后,兩組患者疼痛0級人數(shù)顯著增加,疼痛1、2、3級人數(shù)顯著減少,同組治療前后差異具有統(tǒng)計學意義(P<0.05);治療后,治療組疼痛0級人數(shù)多于對照組,2級人數(shù)顯著少于對照組,兩組比較差異有統(tǒng)計學意義(P<0.05)。結論 腫痛安膠囊聯(lián)合鹽酸米諾環(huán)素治療智齒冠周炎具有很好的臨床效果,能改善盲袋內革蘭氏染色情況,緩解患者疼痛,具有一定的臨床推廣應用價值。

Objective To investigate the clinical efficacy of Zhongtong'an Capsules combined with minocycline hydrochloride in treatment of wisdom tooth pericoronitis. Methods Patients (106 cases) with wisdom tooth pericoronitis in Fengxian Hospital of Fengxian District in Shanghai from January 2015 to January 2016 were randomly divided into the control and treatment groups, and each group had 53 cases. Patients in the control group were given Minocycline Hydrochloride Ointment in periodontal pocket until some overflow, once daily. The patients in the treatment group were po administered with Zhongtong'an Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and Gram's staining, GI, and relief situation of pain in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 84.91%and 96.23%, respectively, and there were differences between two groups (P < 0.05). After treatment, bacterial density, helix, G^-, and GI were significantly reduced, G⁺ was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, patients in two groups of pain level 0 were significant increased, and patients of pain level 1, 2, and 3 was significantly reduced, and the difference was statistically significant in the same group (P < 0.05). After treatment, patients in treatment group of pain level 0 were more than those in the control group, and patients of pain level 2 were less than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Zhongtong'an Capsules combined with minocycline hydrochloride has clinical curative effect in treatment of wisdom tooth pericoronitis, and can improve the gram staining of blind bag, and also relieve the pain of patients, which has a certain clinical application value.