1、FEV₁%、PEF明顯升高,同組治療前后比較差異具有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標的升高幅度均明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。治療1、3個月后,兩組ACT評分明顯升高,同組治療前后比較差異具有統(tǒng)計學(xué)意義(P<0.05);且治療組這些觀察指標的升高幅度均明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 多索茶堿片聯(lián)合吸入用布地奈德混懸液可有效治療支氣管哮喘,降低患者嗜酸性粒細胞比例、FeNO、細胞因子,改善哮喘癥狀和肺功能,升高ACT評分,值得臨床推廣和應(yīng)用。;Objective To discuss the clinical effect of Doxofylline Tablets combined with Budesonide Suspension for inhalation in treatment of bronchial asthma. MethodsPatients (96 cases) with bronchial asthma in Yan'an People's Hospital from January 2014 to July 2015 were randomly divided into the control and treatment group, and each group had 48 cases. The patients in the control group were given udesonide Suspension for inhalation 200 μg, once daily. The patients in the treatment group were po administered with Doxofylline Tablets on the basis of the control group 0.2 g, twice daily. The patients in two groups were treated for 3 months. After treatment, the efficacy was evaluated, and disappearance times of clinical symptoms, eosinophils count, FeNO, cytokines, pulmonary function, and ACT score in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 77.1% and 91.7%, respectively, and there were differences between two groups (P < 0.05). After treatment, the wheeze disappeared time, wheezing disappearance time, and cough disappeared time in treatment group were shorter than those in control group, with significant difference between two groups (P < 0.05). After treatment for 1 and 3 months, eosinophils count FeNO, and IL-4 level in two groups were significantly decreased, but IFN-γ level, FVC, FEV₁, FEV₁%, PEF, and ACT score were significantly increased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Doxofylline Tablets combined with Budesonide Suspension for inhalation has clinical curative effect in treatment of bronchial asthma, and can decrease eosinophils count, FeNO, and cytokines, improve asthma symptoms and pulmonary function, increase ACT scores, , which has a certain clinical application value. Objective To observe the clinical effects of Deproteinised Calf Blood Serum Injection combined with butylphthalide in treatment of acute ischemic cerebral infarction. Methods Patients (250 cases) with acute ischemic cerebral infarction in Tangshan Rehabilitation Medical Center from May 2013 to May 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 125 cases. The patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 100 mL/time, twice daily, and intravenous drip time was longer than 50 min. The patients in the treatment group were iv administered with Deproteinised Calf Blood Serum Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of NDS score, SOD, and MDA in two groups before and after treatment were compared. ResultsAfter treatment, the total efficacies in the control and treatment groups were 69.6% and 86.4%, respectively, and there were differences between two groups (P < 0.05). After treatment, NDS scores and MDA in two groups were significantly decreased, and SOD was significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Deproteinised Calf Blood Serum Injection combined with butylphthalide has clinical curative effect in treatment of acute ischemic cerebral infarction, and can improve nerve function defect with good safety, which has a certain clinical application value. Objective To observe the clinical effect of alprostadil combined with alteplase in treatment of acute cerebral infarction. Methods Patients (120 cases) with acute cerebral infarction in Yantai Longkuang Central Hospital from December 2011 to Apirl 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 60 cases. Patients in the control group were given Alteplase for injection, 5 mg added into 10 mL normal saline, within 10 s for iv injection, and 45 mg added into 100 mL normal saline, within 60 min for iv drip. The patients in treatment group were iv administered with Alprostadil Injection on the basis of the control group, 20 μg added into 250 mL normal saline, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and National Institute of Health stroke scale (NIHSS) scores, Barthel index (BI), vascular recanalization, and cerebral infarction size before and after treatment in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 86.67% and 93.33%, respectively, and there were differences between two groups (P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but BI scores were significantly increased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the NIHSS and BI scores in the treatment group were significantly better than those in the control group, and there were significant differences between two groups (P < 0.05). There was no significant difference in vascular recanalization between two groups. Cerebral infarction size in two groups were significantly decreased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the difference value of cerebral infarction size in the treatment group was significantly better than those in the control group with significant differences (P < 0.05). Conclusion Alprostadil combined with alteplase has clinical curative effect in treatment of acute cerebral infarction, and can significantly improve nerve function, and increase ability of daily life, which has a certain clinical application value. Objective To observe the clinical effect of Yangxue Qingnao Granules combined with Oxiracetam Capsules in treatment of vascular cognitive impairment. Methods Patients (76 cases) with vascular cognitive impairment in North China Petroleum Hospital from January 2014 to October 2015 were divided into the control and treatment groups according to the random number table, and each group had 38 cases. The patients in control group were po administered with Oxiracetam Capsules, 0.8g/time, three times daily. The patients in the treatment group were po administered with Yangxue Qingnao Granules on the basis of the control group, 4 g/time, three times daily. The patients in two groups were treated for 3 months. After treatment, the efficacy was evaluated, and the changes of cognitive function, local cerebral blood flow, sleep disorder, and related event potential P300 were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 68.4% and 94.7%, respectively, and there were differences between two groups (P < 0.05). After treatment, MMSE scores in two groups were significantly increased, VaDAS-Cog score were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, PSQI score in treatment group was significantly decreased, and the difference was statistically significant in the same group (P < 0.05). Local cerebral blood flow and PSQI score in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, amplitude of related event potential P300 in two groups were significantly increased, latency of related event potential P300 were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). These observational indexes in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). Conclusion Yangxue Qingnao Granules combined with Oxiracetam Capsules has clinical curative effect in treatment of vascular cognitive impairment, can significantly improve cognitive function, can obviously promote the increase of local cerebral blood flow, and significantly relieve sleep disorders and related event potential P300, , which has a certain clinical application value. Objective To investigate the clinical efficacies of Tianmai Xiaoke Tablets combined with rosiglitazone in treatment of type 2 diabetes mellitus. Methods Patients (86 cases) with type 2 diabetes mellitus in Department of Endocrinology of Shanghai Putuo District Central Hospital from March 2014 to November 2015 were randomly divided into control and treatment groups, and each group had 43 cases. The patients in the control group were po administered with Rosiglitazone Sodium Tablets, 1 tablet/time, once daily, and the maximum dose was 2 tablets/d. The patients in the treatment group were po administered with Tianmaixiaoke Tablets on the basis of the control group, 2 tablets/time, twice daily. The patients in two groups were treated for 12 weeks. After treatment, the efficacy was evaluated, and the changes of blood lipid, blood glucose, homeostasis model assessment-β (HOMA-β), insulin resistance index (HOMA-IR), serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there were differences between two groups (P < 0.05). After treatment, TG, TC, and LDL-C in two groups were obviously decreased, HDL-C was increased, and the difference was statistically significant (P < 0.05). And TG, TC, LDL-C and HDL-C improved better than those in the control group, with significant differences between two groups (P < 0.05). After treatment, FPG, 2 h PG and HbAlc levels in two groups were decreased more obviously (P < 0.05); And the reducing degrees in treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, HOMA-β was significantly increased, HOMA-IR was significantly decreased, and there were significant differences between two groups before and after treatment (P < 0.05); And the improvement of HOMA-β and HOMA-IR in the treatment group were better than those in control group, with significant difference between two groups (P < 0.05). After treatment, serum TNF-α and IL-6 in two groups were significantly decreased (P < 0.05); TNF-α and IL-6 in treatment group were decreased more significantly than those in the control group (P < 0.05). Conclusion Tianmai Xiaoke Tablets combined with Rosiglitazone Sodium Tablets has good clinical efficacy in treatment of type 2 diabetes mellitus, can significantly decrease insulin resistance and improve insulin sensitivity, and is conducive to correct dyslipidemia and reduce inflammation, which has a certain clinical application value. Objective To investigate the clinical effect of Tongxinluo Capsules combined with buflomedil in treatment of lower extremity vascular lesionsin in type 2 diabetes. Methods Patients (90 cases) with lower extremity vascular lesionsin in type 2 diabetes in the Liuzhou Worker's Hospital from March 2015 to March 2016 were divided into control group (45 cases) and treatment group (45 cases) according to different treatment plans. The patients in the control group were iv administered with Buflomedil Hydrochloride Injection, 0.2 g added into 5% glucose solution 500 mL, once daily. The patients in the treatment group were po administered with Tongxinluo Capsules on the basis of the control group, 4 grains/time, three times daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of FBG, 2 hPG, HbA1c, CP, HCT, PAR, FIB, TNF-α, IL-6, hs-CRP, MDA, SOD, ABI score, and dorsalis pedis artery diameter in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control group and treatment group were 82.22% and 95.56%, respectively, and there were differences between two groups (P < 0.05). After treatment, FPG, 2 hPG, HbAlc, IL-6, TNF-α, hs-CRP, MDA, CP, HCT, PAR, and FIB in two groups were significantly decreased, and SOD, ABI, and dorsalis pedis artery diameter in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Tongxinluo Capsules combined with buflomedil has good clinical efficacy in treatment of lower extremity vascular lesionsin in type 2 diabetes, and can obviously improve the foot back blood flow and blood rheology indicators, and can reduce the inflammatory response, which has a certain clinical application value. Objective To observe the clinical effects of Shuxuetong Injection combined with Calcium Dobesilate Capsules in treatment of simple diabetic retinopathy. Methods Patients (81 cases) with simple diabetic retinopathy in First Hospital of Qinhuangdao from October 2013 to April 2015 were randomly divided into control group (40 cases) and treatment group (41 cases). Patients in two groups were given conventional treatment to control blood sugar. The patients in the control group were po administered with Calcium Dobesilate Capsules, 0.5 g/time, three times daily. The patients in the treatment group were iv administered with Shuxuetong Injection on the basis of the control group, 6 mg added into normal saline 250 mL, once daily. Two groups were treated for 1 month. After treatment, the total efficacy was evaluated, and the changes of vision and blood rheology indexes in two groups were compared. Results After treatment, the clinical effects in the control and treatment groups were 75.00% and 95.12%, respectively, and there was difference between two groups (P < 0.05). After treatment, vision in the treatment group was improved more significantly than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, blood rheology indexes in two groups were lower than those in the same group before treatment (P < 0.05). And the trp, with significant difference between two groups (P < 0.05). After treatment, the levels of PLT and IL-4 in two groups were significantly increased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, hemostatic time, and platelet count up to normal time in the treatment group were shorten than those in the control group, and there were differences between two groups (P < 0.05). Conclusion Mannatide Oral Solution combined with human immunoglobulin has clinical curative effect in treatment of idiopathic thrombocytopenic purpura, and can improve the immune capacity of patients, accelerate hemostasis, which has a certain clinical application value. Objective To explore the clinical effect of saccharomyces boulardii combined with Shuganning Injection in treatment of neonatal hyperbilirubinemia. Methods Children (70 cases) with neonatal hyperbilirubinemia in the Affiliated People's Hospital of Hubei Medical College from June 2014 to June 2015 were randomly divided into the control and treatment groups, and each group had 35 cases. Children in the control group were iv administered with Shuganning Injection, 10 mL added into 10% glucose injection 250 mL, once daily. And after symptomatic relief, iv administration could be replaced by im administration, 2 mL/time, once daily. Children in the treatment group were given with Saccharomyces Boulardii Sachets on the basis of the control group, 1 bag/time, once daily. Children in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and bilirubin levels and common clinical indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 94.92%, respectively, and there were difference between two groups (P < 0.05). After treatment, serum bilirubin levels and transcutaneous bilirubin levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, bilirubin daily average decline in the treatment was significantly greater than that in the control group, but jaundice subsided time, and blue ray treatment time in the treatment group were obviously shorter than those in the control group, and the observational indexes were significant differences between two groups (P < 0.05). Conclusion Saccharomyces boulardii combined with Shuganning Injection has clinical curative effect in treatment of neonatal hyperbilirubinemia, and can reduce bilirubin levels, shorten jaundice subsided time and blue ray treatment time, which has a certain clinical application value. Objective To evaluate the clinical efficacy and safety of Fuganlin Oral Liquid in treatment of common cold in children with qi deficiency and wind heat syndrome. Methods The stratified random, double blind, double dummy, parallel control of positive drugs, and multi-center clinical method were applied to this study. Patients (467 cases) were randomly divided into control group (117 cases) and treatment group (350 cases). Patients in the control group were administered with Xiaoer Jiebiao Oral Liquid and simulation of Fuganlin Oral Liquid, while patients in the treatment group were administered with Fuganlin Oral Liquid and simulation of Xiaoer Jiebiao Oral Liquid. The patients in two groups were treated for one week. Clinical efficacy, traditional Chinese medicine syndrome, and single syndrome disappearance rate were observed. And the medication compliance and security were evaluated. Results The curative rates of treatment and control groups in clinical efficacy were 82.91% and 98.29%, and the clinical curative rates of both groups in traditional Chinese medicine syndrome effect were 84.62% and 98.29%. And there were differences between two groups (P < 0.05). The single syndrome disappearance rates of fever, aversion to wind, pharyngodynia, and cough in the treatment group were higher than those in the control group with significant differences (P < 0.05). There was no significant difference in single syndrome disappearance rate of rhinobyon and rhinorrhoea between two groups. And there was no significant difference in adverse event/reaction rate between two groups. Conclusion Fuganlin Oral Liquid has a good effect in treatment?of com?on cold in children with qi deficiency and wind heat syndrome with good safety, which has a certain clinical application value. Objective To investigate the clinical efficacy of Compound Kushen Injection combined with megestrol acetate in treatment of endometrial carcinoma. Methods Pastiffness score, daily activity score, comprehensive score, IL-1β, TNF-α, COMP, and MMP-3 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Zhengqing Fengtongning Tablets combined with meloxicam has good clinical efficacy in treatment of osteoarthritis, and can obviously improve the clinical symptoms, and can reduce serum inflammatory indicators, which has a certain clinical application value. ObjectiveTo investigate the clinical effect of Shenfu Injection combined with Human Immunoglobulin (pH 4) for intravenous injection in treatment of kawasaki disease. Methods Children (128 cases) with kawasaki disease in Dianjiang People's Hospital of Chongqing from May 2013 to May 2015 were divided into the control and treatment groups, and each group had 64 cases. Children in two groups were given conventional therapy. Children in the control group were iv administered with Human Immunoglobulin (pH 4) for intravenous injection on the basis of the conventional therapy, 2 g/kg, only once. Children in the treatment group were iv administered with Shenfu Injection on the basis of the control group, 4 mL added into 5% glucose 100 mL, once daily. Children in two groups were treated for 15 d. After treatment, the efficacies were evaluated, and routine blood, defervescence time, hospitalization time, erythrocyte sedimentation rate, and C-reactive protein in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.6% and 92.2%, respectively, and there was difference between two groups (P < 0.05). After treatment, white cells in two groups was significantly decreased, but platelets and hemoglobin in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, defervescence time and hospitalization time in the treatment group were obviously shorter than those in the control group, and there was difference between two groups (P < 0.05). After treatment, erythrocyte sedimentation rate and C-reactive protein in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Shenfu Injection combined with Human Immunoglobulin (pH 4) for intravenous injection has clinical curative effect in treatment of kawasaki disease, and can improve hematological indexes, shorten hospitalization time, which has a certain clinical application value. Objective To investigate the clinical efficacies of Huoxue Zhitong Capsules combined with Ossotide Injection in the treatment of knee osteoarthritis. Methods Patients (78 cases) with knee osteoarthritis in the First People's Hospital of Neijiang from January 2015 to January 2016 were divided into control group (39 cases) and treatment group(39 cases) according to different treatment plans. The patients in the control group were intra-articular injected with Ossotide Injection, 30 mg/time, once a week. The patients in the treatment group were po administered with Huoxue Zhitong Capsules on the basis of the control group, 6 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacies between two groups were compared. And the changes of Lequesne indexes and visual analogue scores in two groups were observed. Equally, the levels of blood IL-1β, TNF-α, MMP-9 and NO in two groups before and after treatment were detected. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there were differences between two groups (P < 0.05). After treatment, Lequesne indexes and visual analogue scores in two groups were significantly decreased (P < 0.05). Furthermore, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of blood IL-1β, TNF-α, MMP-9, and NO in two groups weresignificantly decreased (P < 0.05), and the reductions in treatment group were more obvious, with significant difference between two groups (P < 0.05). Conclusion Huoxue Zhitong Capsules combined with Ossotide Injection has significant clinical efficacies in the treatment of knee osteoarthritis, can improve knee joint functions and reduce joint pains and inflammatory factors levels in serum, which has a certain clinical application value. Objective To investigate the clinical effect of Mannatide Oral Solution combined with human immunoglobulin in treatment of idiopathic thrombocytopenic purpura. Methods Patients (74 cases) with idiopathic thrombocytopenic purpura in Shanghai Pudong Hospital from August 2014 to August 2015 were randomly divided into the control and treatment groups, and each group had 37 cases. Patients in the control group were iv administered with Human Immunoglobulin (pH 4) for intravenous injection, 0.4 g/kg, once daily. Patients in the treatment group po administered with Mannatide Oral Solution on the basis of the control group, 1 tube/time, three times daily. Patients in two groups were treated for 4 week. After treatment, the efficacies were evaluated, and T lymphocyte subsets, platelet-associated antibody, PLT, IL-4, hemostatic time, and platelet count up to normal time in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 78.38% and 94.59%, respectively, and there was difference between two groups (P < 0.05). After treatment, the levels of CD³⁺ and CD⁴⁺, and CD⁴⁺/CD⁸⁺ ratio in two groups were significantly increased, but level of CD⁸⁺ in two groups observably decreased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of PA IgG, PA IgA, and PA IgM in in two groups observably decreased, and the differences were statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control grou