目的 探究參附注射液聯(lián)合靜注人免疫球蛋白治療川崎病的臨床療效。方法 選取2013年5月-2015年5月重慶市墊江縣人民醫(yī)院收治的川崎病患兒128例,隨機(jī)分為對(duì)照組和治療組,每組各64例。兩組患兒均給予常規(guī)治療,對(duì)照組在常規(guī)治療的基礎(chǔ)上靜脈滴注靜注人免疫球蛋白(pH 4),2 g/kg,1次輸注;治療組在對(duì)照組的基礎(chǔ)上靜脈滴注參附注射液,4 mL加到5%葡萄糖溶液100 mL,1次/d。兩組患兒均治療15 d。治療后,觀察兩組的臨床療效,同時(shí)比較兩組血常規(guī)、退熱時(shí)間、住院時(shí)間、紅細(xì)胞沉降率以及C反應(yīng)蛋白變化情況。結(jié)果 治療后,對(duì)照組和治療組的總有效率分別為76.6%、92.2%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患兒的白細(xì)胞明顯降低,而血小板和血紅蛋白均明顯升高,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組治療后這些觀察指標(biāo)的改善程度明顯優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,治療組退熱時(shí)間和住院時(shí)間明顯短于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患兒的紅細(xì)胞沉降率和C-反應(yīng)蛋白均顯著下降,同組治療前后差異有無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05);且治療組治療后這些觀察指標(biāo)改善程度明顯優(yōu)于對(duì)照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 參附注射液聯(lián)合靜注人免疫球蛋白治療川崎病具有較好的臨床療效,能改善患兒血液學(xué)指標(biāo),縮短住院時(shí)間,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore clinical efficacy of Carboprost Methylate Suppositories combined with Bakri Balloon in treatment of postpartum hemorrhage. Methods Patients (90 cases) with postpartum hemorrhage in Yantai Affiliated Hospital of Binzhou Medical University from June 2014 to June 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 45 cases. Patients in the control group were given one Bakri Balloon in vagina or uterine incision during caesarean section, and then given 200 - 300 mL normal saline. Patients in the treatment group were given one Carboprost Methylate Suppositories in vagina on the basis of the control group. The patients in two groups were treated for 24 h. After treatment, the clinical efficacy, systolic pressure (SBP), diastolic pressure (DBP), and oxygen saturation (SaO₂), amount of bleeding, and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 86.67% and 97.78%, respectively, and there was difference between two groups (P < 0.05). SBP, DBP, and SaO₂ in two groups were improved, and the differences were statistically significant in the same group (P < 0.05). But there was no significant difference in these observational indexes between two groups. After treatment for 2 and 24 h, amount of bleeding in two groups were decreased and the differences were statistically significant in the same group (P < 0.05). The amount of bleeding in the treatment group was lower than that in the control group, with significant differences between two groups (P < 0.05). There was no significant difference in adverse effects rate between two groups. Conclusion Carboprost Methylate Suppositories combined with Bakri Balloon has good effect in treatment of postpartum hemorrhage, can decrease amount of bleeding with good safety, which has a certain clinical application value.