目的 探析注射用曲妥珠單抗聯(lián)合多西紫杉醇注射液治療人類表皮生長因子受體2(Her-2)陽性乳腺癌的臨床療效。方法 選取黃石市中心醫(yī)院(普愛院區(qū))2011年2月-2015年2月收治的乳腺癌患者86例作為研究對(duì)象,所有患者按照就診順序編號(hào)分為對(duì)照組和治療組,每組各43例。對(duì)照組靜脈滴注多西紫杉醇注射液75 mg/m²,1 h內(nèi)滴完,間隔21 d重復(fù)給藥,共給藥4次。治療組在對(duì)照組的基礎(chǔ)上靜脈滴注注射用曲妥珠單抗,將曲妥珠單抗溶于250 mL生理鹽水中,首次劑量4 mg/kg,90 min內(nèi)滴完,之后維持2 mg/kg,1次/周。觀察兩組的客觀有效率、疾病控制率,同時(shí)比較治療前后Her-2表達(dá)、細(xì)胞凋亡相關(guān)因子水平和不良反應(yīng)發(fā)生情況。結(jié)果 治療后,對(duì)照組、治療組的客觀有效率、疾病控制率分別為60.5%、81.4%,70.0%、88.4%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組患者Her-2(＋＋)、(＋＋＋)比例顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組指標(biāo)的降低程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后兩組Caspase-3、DcR3、COX-2水平均顯著降低,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組這些觀察指標(biāo)的降低程度優(yōu)于對(duì)照組,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組不良反應(yīng)均以胃腸道反應(yīng)、皮疹、白細(xì)胞減少、疲倦、心臟毒性等為主,但各種不良反應(yīng)發(fā)生率的差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 注射用曲妥珠單抗聯(lián)合多西紫杉醇注射液治療Her-2陽性乳腺癌具有較好的臨床療效,可有效弱化Her-2表達(dá),降低細(xì)胞凋亡相關(guān)因子水平,安全性佳,值得推廣應(yīng)用。

Neurodegenerative disease is a chronic progressive disease. Its characteristics is the gradual loss of the central nervous system neurons. Due to the presence of the blood-brain barrier, the classical anti-inflammatory drugs such as steroid hormones and non-steroid anti-inflammatory drugs are used in treatment of the nervous system diseases with a limited effect. Therefore, it is important to develop new anti-inflammatory drugs for prevention and treatment of nervous system diseases. Resveratrol is a kind of natural polyphenols with strong activity. At present, the study has shown that resveratrol has the functions of cardiovascular protection, neuroprotection, immunoregulation, and cancer chemopreventive effects. Recently, it has been found the function of resisting nerve inflammation, and is used in treatment of nervous system diseases such as Parkinson's disease, Alzheimer's disease (AD), and Huntington's disease, etc. In order to provide reference for further promoting the research on resveratrol using to the prevention and treatment of AD, research progress on the protective effect and mechanism of resveratrol in treatment of AD is reviewed in this paper.