目的 探討卡前列甲酯栓聯(lián)合Bakri球囊治療產(chǎn)后出血的臨床療效。方法 選取2014年6月-2015年6月濱州醫(yī)學(xué)院煙臺(tái)附屬醫(yī)院收治的產(chǎn)后出血患者90例,隨機(jī)分為對照組和治療組,每組各45例。對照組自陰道或剖宮產(chǎn)術(shù)中子宮切口處置入1個(gè)Bakri球囊,并注入200~300 mL生理鹽水,治療組在對照組基礎(chǔ)上從陰道置入1枚卡前列甲酯栓。兩組患者均治療24 h。比較兩組患者的臨床療效,收縮壓(SBP)、舒張壓(DBP)和血氧飽和度(SaO₂)、出血量以及不良反應(yīng)情況。結(jié)果 治療后,對照組和治療組的總有效率分別為86.67%、97.78%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后,兩組的SBP、DBP和SaO₂均較治療前顯著改善,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);兩組治療后的SBP、DBP和SaO₂比較差異無統(tǒng)計(jì)學(xué)意義;治療2、24 h后,兩組出血量均較治療前明顯減少,同組治療前后差異有統(tǒng)計(jì)學(xué)意義(P<0.05);且治療組的改善程度明顯優(yōu)于對照組,兩組比較差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組不良反應(yīng)發(fā)生率比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 卡前列甲酯栓聯(lián)合Bakri球囊治療產(chǎn)后出血具有較好的臨床療效,可減少出血量,且安全性較高,具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To explore clinical efficacy of Carboprost Methylate Suppositories combined with Bakri Balloon in treatment of postpartum hemorrhage. Methods Patients (90 cases) with postpartum hemorrhage in Yantai Affiliated Hospital of Binzhou Medical University from June 2014 to June 2015 were selected. The patients were randomly divided into control group and treatment group, and each group had 45 cases. Patients in the control group were given one Bakri Balloon in vagina or uterine incision during caesarean section, and then given 200 - 300 mL normal saline. Patients in the treatment group were given one Carboprost Methylate Suppositories in vagina on the basis of the control group. The patients in two groups were treated for 24 h. After treatment, the clinical efficacy, systolic pressure (SBP), diastolic pressure (DBP), and oxygen saturation (SaO₂), amount of bleeding, and adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 86.67% and 97.78%, respectively, and there was difference between two groups (P < 0.05). SBP, DBP, and SaO₂ in two groups were improved, and the differences were statistically significant in the same group (P < 0.05). But there was no significant difference in these observational indexes between two groups. After treatment for 2 and 24 h, amount of bleeding in two groups were decreased and the differences were statistically significant in the same group (P < 0.05). The amount of bleeding in the treatment group was lower than that in the control group, with significant differences between two groups (P < 0.05). There was no significant difference in adverse effects rate between two groups. Conclusion Carboprost Methylate Suppositories combined with Bakri Balloon has good effect in treatment of postpartum hemorrhage, can decrease amount of bleeding with good safety, which has a certain clinical application value.