目的 分析南京市婦幼保健院抗菌藥物的使用情況,為臨床合理用藥提供依據(jù)。方法 隨機(jī)抽取2012年1月-2015年12月門(mén)診抗菌藥物處方15 910張,對(duì)抗菌藥物的聯(lián)用情況、給藥途徑、用藥頻度(DDDs)和藥物利用指數(shù)(DUI)等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 門(mén)診抗菌藥物處方15 910張,占門(mén)診總處方14.36%,抗菌藥物使用品種為30種,單一用藥處方數(shù)最多,為13 555張(85.20%),二聯(lián)和三聯(lián)用藥分別占12.90%、1.90%;抗菌藥物處方中使用較多的分別為頭孢菌素類(lèi)、大環(huán)內(nèi)酯類(lèi)和青霉素類(lèi);給藥途徑主要為口服,構(gòu)成比為79.82%;鹽酸左氧氟沙星注射液的DDDs較高,注射用頭孢硫脒、注射用頭孢西丁鈉的DDDs較低,羅紅霉素分散片和頭孢克洛分散片的DUI>1.0。不合理用藥率為4.64%,其中主要為無(wú)指征用藥、用法用量不當(dāng)和選藥不適宜。結(jié)論 南京市婦幼保健院抗菌藥物使用率較高,需規(guī)范使用,減小抗菌藥物使用強(qiáng)度,盡量避免不合理應(yīng)用,確保用藥安全有效。

Objective To analyze the use of antibiotics in Nanjing Maternity and Child Health Care Hospital, and to provide basis for reasonable application of antibiotics. Methods Antibacterial prescriptions (15 910 pieces) in Department of Outpatient in Nanjing Maternity and Child Health Care Hospital from January 2012 to December 2015 were randomly selected. Combination, route of administration, frequency of drug use (DDDs), and drug utilization index (DUI) were analyzed statistically. Results There were 15 910 pieces of antibacterial prescriptions from Department of Outpatient, accounting for 14.36% in total prescriptions of outpatients. There were 30 kinds of antibiotics, in which 13 555 pieces (85.20%) only used one kinds of antibiotics, and rates of double-drug and triple-drug were 12.90% and 1.90%, respectively. The most use of antibacterial prescriptions was cephalosporins, macrolides, and penicillins. The main administration route was oral administration, accounting for 79.82%. DDDs of Levofloxacin Hydrochloride Injection were higher, while DDDs of Cephathiamidine for injection and Cefoxitin Sodium for injection were lower. DUI of Roxithromycin Dispersible Tablets and Cefaclor Dispersible Tablets were more than 1.0. The unreasonable rate of antibiotics was 4.64%. The main types of unreasonable medicine were unclear indications, improper dosage and administration, and inappropriate choice of medicine. Conclusion Usage of antibiotics is higher in Nanjing Maternity and Child Health Care Hospital, therefore it should be taken standardized use of antibiotics to reduce the intensity use of antimicrobial drugs, and to avoid unreasonable application to ensure safe and effective medication.