目的 探討上海市嘉定區(qū)中心醫(yī)院中藥注射劑致不良反應(ADR)發(fā)生的成因和特點,為臨床合理用藥提供參考。方法 對2013－2015年上海市嘉定區(qū)中心醫(yī)院臨床上報的65例中藥注射劑ADR報告進行統(tǒng)計分析。結(jié)果 65例ADR報告中,女性比例略高于男性,年齡主要集中在50~60歲;無過敏史的患者49例,構(gòu)成比為75.38%;最易引發(fā)ADR的藥品為血栓通注射液、參麥注射液、骨肽注射液;靜脈滴注后1~7 d發(fā)生ADR的例數(shù)最多;以皮膚及附件損害、全身損傷較為多見,所占構(gòu)成比分別為61.54%、20.00%;59例(90.77%)與其他藥物聯(lián)合用藥。結(jié)論 臨床應加強中藥注射劑ADR的監(jiān)測與上報工作,以保障合理用藥與患者安全。

Objective To explore the causes and characteristics of adverse drug reactions (ADR) caused by traditional Chinese medicine injections in Shanghai Jiading District Central Hospital, and to provide reference for improving clinical rational drug use. Methods ADR reports (65 cases) induced by traditional Chinese medicine injections in Shanghai Jiading District Central Hospital from 2013 to 2015 were analyzed statistically. Results Among ADR reports (65 cases), women with ADR induced by traditional Chinese medicine injections were more than men, and more were focused on 50 - 60 years old. There were 49 cases of patients without history of allergies, accounting for 75.38%. The drugs most easily triggering ADR were Xueshuantong Injection, Shenmai Injection, and Ossotide Injection. The most cases occured during 1 - 7 d after the intravenous drip. The main ADR were skin and its appendages injury (61.54%) and systemic injury (20.00%). There were 59 cases (90.77%) of ADR caused by combination with other drugs. Conclusion More attention should be paid on the ADR monitoring and reporting of traditional Chinese medicine injections to promote clinical rational use and safe medication.