表沒食子兒茶素沒食子酸酯(EGCG)是綠茶中的主要兒茶素,大量研究表明綠茶在治療嚴(yán)重慢性疾病如心血管病、神經(jīng)退行性病變、腫瘤、代謝綜合征、2型糖尿病等方面發(fā)揮了積極的生物學(xué)作用。綠茶的這種保護(hù)性作用主要?dú)w因于EGCG強(qiáng)有力的抗氧化活性。EGCG的抗氧化作用機(jī)制主要包括清除自由基、金屬螯合、抑制細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)通路、調(diào)節(jié)氧化和抗氧化酶系等。綜述了其抗氧化機(jī)制的研究進(jìn)展,以期為臨床應(yīng)用及開發(fā)相同或相似機(jī)制的藥物提供理論依據(jù)。

Epigallocatechin gallate (EGCG) is the main catechin in green tea. A large number of researches have revealed that green tea demonstrates a wide range of positive biological activities against serious chronic diseases, such as cardiovascular disease, neurodegenerative disorders, cancer, metabolic syndrome, and type 2 diabetes. These protective properties can be traced back to the potent antioxidant activities of EGCG. Recent studies have suggested that EGCG may exert its anti-oxidant effects by scavenging free radicals, metal chelation, inhibition of transcription factor activation, and adjusting the oxidation and anti-oxidant enzyme system, etc. This paper summarizes the research progress on anti-oxidative mechanism of EGCG, in order to provide reference for exploiting drugs with same or similar mechanism of EGCG for clinical application.