神經(jīng)退行性疾病是一種慢性進(jìn)展性疾病,其特點(diǎn)是中樞神經(jīng)系統(tǒng)神經(jīng)元的逐漸喪失。由于血腦屏障的存在,經(jīng)典的抗炎藥物如類固醇激素和非甾體類抗炎藥,對(duì)神經(jīng)系統(tǒng)疾病的治療作用有限。因此,開發(fā)新的抗炎藥物,對(duì)于預(yù)防和治療神經(jīng)系統(tǒng)疾病具有重要的意義。白藜蘆醇是一種有很強(qiáng)活性的天然多酚類物質(zhì),目前研究已顯示其具有心血管保護(hù)、神經(jīng)保護(hù)、免疫調(diào)節(jié)、腫瘤的化學(xué)預(yù)防作用。近年來(lái)還發(fā)現(xiàn)其具有抗神經(jīng)炎癥作用,可用于治療神經(jīng)精神性疾病,如帕金森病、阿爾茨海默病(AD)和亨廷頓癥等。綜述白藜蘆醇對(duì)AD的保護(hù)作用及其機(jī)制研究進(jìn)展,為進(jìn)一步推進(jìn)白藜蘆醇用于防治AD的研究提供參考。

Neurodegenerative disease is a chronic progressive disease. Its characteristics is the gradual loss of the central nervous system neurons. Due to the presence of the blood-brain barrier, the classical anti-inflammatory drugs such as steroid hormones and non-steroid anti-inflammatory drugs are used in treatment of the nervous system diseases with a limited effect. Therefore, it is important to develop new anti-inflammatory drugs for prevention and treatment of nervous system diseases. Resveratrol is a kind of natural polyphenols with strong activity. At present, the study has shown that resveratrol has the functions of cardiovascular protection, neuroprotection, immunoregulation, and cancer chemopreventive effects. Recently, it has been found the function of resisting nerve inflammation, and is used in treatment of nervous system diseases such as Parkinson's disease, Alzheimer's disease (AD), and Huntington's disease, etc. In order to provide reference for further promoting the research on resveratrol using to the prevention and treatment of AD, research progress on the protective effect and mechanism of resveratrol in treatment of AD is reviewed in this paper.