目的 探討仙靈骨葆膠囊聯(lián)合伊班膦酸鈉注射液和碳酸鈣D₃治療老年骨質(zhì)疏松癥的臨床療效。方法 選取2013年3月—2014年3月郫縣人民醫(yī)院收治的骨質(zhì)疏松癥患者74例，按治療方法的不同分為對照組和治療組，每組各37例。對照組患者靜脈滴注伊班膦酸鈉注射液，2 mg加入生理鹽水250 mL，滴注時間≥2 h，3個月1次；同時口服碳酸鈣D₃片，1片/d。治療組在此基礎(chǔ)上口服仙靈骨葆膠囊，2粒/次，3次/d。兩組患者均治療12個月。觀察兩組的臨床療效，同時比較兩組治療前后血鈣（S-Ca）、血磷（S-P）、堿性磷酸酶（ALP）、骨密度（BMD）和骨鈣素（BGP）的變化情況。結(jié)果 治療后，對照組和治療組的總有效率分別為78.38%、89.19%，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者S-P、ALP均顯著降低，且S-Ca升高，同組治療前后差異具有統(tǒng)計學(xué)意義（P<0.05）；且治療組上述指標(biāo)改善程度優(yōu)于對照組（P<0.05）。治療后，兩組患者腰椎L2-L4 BMD、股骨頸BMD和BGP均顯著升高（P<0.05）；且治療組升高更明顯，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 仙靈骨葆膠囊聯(lián)合伊班膦酸鈉注射液和碳酸鈣D₃治療老年骨質(zhì)疏松癥療效確切，可有效增加患者BMD，并能明顯改善骨代謝和骨轉(zhuǎn)換狀態(tài)，具有一定的臨床推廣應(yīng)用價值。

Objective To investigate the clinical effect of Xianling Gubao Capsules combined with Sodium Ibandronate Injection and calcium carbonate D₃ in treatment of osteoporosis. Methods Patients (74 cases) with osteoporosis in Pixian People's Hospital from March 2013 to March 2014 were divided into control and treatment groups according to the different treatments, and each group had 37 cases. The patients in the control group were iv administered with Sodium Ibandronate Injection, 2 mg added to normal saline 250 mL, drip time≥2 h, once 3 months. And they were po administered with Calcium Carbonate D₃ Tablets, 1 tablet/d. The patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of control group, 2 grains/time, three times daily. The patients in two groups were treated for 12 months. After treatment, the clinical efficacy was evaluated, and the changes of S-Ca, S-P, ALP, BMD, and BGP in two groups before and after treatment were compared. Results After treatment, the clinical effect in the control and treatment groups were 78.38% and 89.19%, respectively, and there were differences between two groups (P<0.05). After treatment, S-P and ALP in two groups were significantly decreased, but S-Ca was increased, and the difference was statistically significant in the same group (P<0.05); The observational indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, L2-L4 BMD femoral neck BMD and BGP were significantly increased, and the difference was statistically significant in the same group (P<0.05); And the increase degree of these observational indexes in the treatment group was more significantly than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xianling Gubao Capsules combined with Sodium Ibandronate Injection and calcium carbonate D₃ in treatment of osteoporosis has a good clinical effect, can effectively increase BMD, and improve the bone metabolism and bone turnover status, which has a certain clinical application value.