目的 探討天津市職業(yè)病防治院抗抑郁藥的使用情況及變化趨勢(shì)，為促進(jìn)臨床合理用藥提供依據(jù)。方法 對(duì)天津市職業(yè)病防治院2011—2015年抗抑郁癥用藥的用藥金額、用藥頻度（DDDs）、日均費(fèi)用（DDC）和用藥科室分布等進(jìn)行統(tǒng)計(jì)分析。結(jié)果 抗抑郁藥的用藥金額和DDDs總體上均呈現(xiàn)逐年增長(zhǎng)的趨勢(shì)；臨床上抗抑郁藥以合資和進(jìn)口藥品為主，國(guó)產(chǎn)藥品占比較小，但逐年有小幅增長(zhǎng)；除2013年外，舍曲林一直是DDDs值最高的品種。大部分抗抑郁藥物的DDC值相對(duì)穩(wěn)定，有部分抗抑郁藥的DDC值在2013年發(fā)生下降。2014、2015年用藥科室數(shù)量均減少到8個(gè)，且抗抑郁藥DDDs排名第1位的一直是心理科門診。結(jié)論 2011—2015年天津市職業(yè)病防治院抗抑郁藥的應(yīng)用基本合理，新型抗抑郁藥是臨床首選，用藥空間廣泛。

Objective To discuss the use and trends of antidepressants in Tianjin Occupational Diseases Precaution and Therapeutic Hospital, in order to provide reference for rational drug use in clinic. Methods Consumption sum, frequency of drug use (DDDs), average daily cost (DDC), and distribution of medicine department were analyzed statistically. Results Consumption sum and DDDs both showed an increasing tendency year by year. Main antidepressants in clinic were drugs of import and joint investment, while those made in China accounted for the relatively small, but had a slight increased year by year. Except 2013, DDDs of sertraline ranked the first during 2011-2015. DDC of most antidepressants was stable, while DDC of some drugs decreased in 2013. The number of medicine department both decreased to eight in 2014 and 2015. DDDs of Department of Psychologist always ranked the first. Conclusion The utilization of antidepressants in Tianjin Occupational Diseases Precaution and Therapeutic Hospital during 2011-2015 is basically rational. New antidepressants are the first choice in clinic, and have broad growth space.