目的 分析非甾體抗炎藥致上消化道出血的臨床特征。方法 選取天津市第一中心醫(yī)院2012年10月—2015年6月消化道出血的住院患者110例，對其臨床資料進行分析統(tǒng)計。按照出血前10 d內(nèi)是否服用過非甾體抗炎藥為標準對患者進行分組，比較兩組的臨床特征。結(jié)果 兩組患者在急性胃黏膜病變、胃底和胃竇胃潰瘍、心血管病史以及前壁和后壁十二指腸潰瘍方面存在顯著差異，兩組比較具有統(tǒng)計學(xué)意義（P<0.05）。其中用藥組的急性胃黏膜病變、胃底和胃竇胃潰瘍、心血管病史所占比例大于非用藥組，而用藥組的前壁和后壁十二指腸潰瘍所占比例小于非用藥組。結(jié)論 在臨床治療過程中，需要采取適當(dāng)?shù)拇胧┯行У亟档头晴摅w抗炎藥所致的上消化道出血等不良反應(yīng)。

Objective To analyze the clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs. Methods Inpatients (110 cases) with upper gastrointestinal bleeding in Tianjin First Center Hospital from November 2012 to June 2015 were selected, and the clinical data were retrospectively analyzed. The patients were divided into two groups according to the criterion whether taking NSAIDs in 10 d before bleeding, and the clinical characteristics between two groups were compared. Results There were significant difference in acute gastric mucosal lesion, gastric ulcer of fundus and antrum, a history of cardiovascular disease, and duodenal ulcer of antetheca and backwall between two groups (P<0.05). The proportion of acute gastric mucosal lesion, gastric ulcer of fundus, and antrum, and a history of cardiovascular disease in the drug group was higher than that in non-drug group. While the proportion of duodenal ulcer of antetheca and backwall was lower than that in non-drug group. Conclusion Some actions should be taken to reduce adverse reactions such as upper gastrointestinal bleeding induced by NSAIDs in the treatment progress.