目的 探討龍血竭膠囊聯(lián)合硫辛酸和前列地爾治療糖尿病足的臨床療效。方法 選取2015年1月-2016年1月在雄縣醫(yī)院接受治療的糖尿病足患者88例，隨機(jī)分為對(duì)照組和治療組，每組各44例。對(duì)照組靜脈滴注硫辛酸注射液，0.6 g加入到0.9%氯化鈉溶液250 mL中，1次/d；且還靜脈滴注前列地爾注射液，20 μg加入到0.9%氯化鈉溶液250 mL中，1次/d。治療組在對(duì)照組基礎(chǔ)上口服龍血竭膠囊，4粒/次，3次/d。兩組患者均治療4周。觀察兩組的臨床療效，比較兩組血液流變學(xué)指標(biāo)、炎癥指標(biāo)、踝臂血壓指數(shù)（ABI）、足趾皮膚溫度的情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為81.82%、95.45%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的血細(xì)胞比容（HCT）、纖維蛋白原（FIB）、紅細(xì)胞聚集指數(shù)（RF）及全血高切黏度（HS）均明顯降低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的降低程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、成纖維細(xì)胞生長(zhǎng)因子2（FGF2）、血管細(xì)胞黏附分子-1（VCAM-1）均明顯將低，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的降低程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者ABI及足趾皮膚溫度均明顯升高，同組治療前后差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的升高程度明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 龍血竭膠囊聯(lián)合硫辛酸和前列地爾治療糖尿病足具有較好的臨床療效，能夠明顯緩解患者臨床癥狀，改善血液流變學(xué)指標(biāo)及炎癥指標(biāo)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Longxuejie Capsules combined with thioctic acid and alprostadil in treatment of diabetic foot. Methods Patients (88 cases) with diabetic foot in Xiongxian Hospital from January 2013 to January 2015 were randomly divided into the control and treatment groups, and each group had 44 cases. Patients in the control group were iv administered with Thioctic Acid Injection, 0.6 g added in normal saline 250 mL, once daily. And Patients in the control group were also iv administered with Alprostadil Injection, 20 μg added in normal saline 250 mL, once daily. Patients in the treatment group were po administered with Longxuejie Capsules on the basis of the control group, 4 grains/time, three times daily. After treatment, the clinical efficacies were evaluated, and blood rheology indexes, inflammation indexes, ABI, and toe skin temperature in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.82% and 95.45%, respectively, and there was difference between two groups (P<0.05). After treatment, HCT, FIB, RF, and HS in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, IL-6, TNF-α, FGF2, and VCAM-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, ABI and toe skin temperature in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Conclusion Longxuejie Capsules combined with thioctic acid and alprostadil has clinical curative effect in treatment of diabetic foot, and can significantly improve clinical symptoms, blood rheology indexes, and inflammation indexes, which has a certain clinical application value.