目的 比較纈沙坦和氨氯地平治療原發(fā)性高血壓的臨床療效。方法 選取2012年12月-2015年12北京市垂楊柳醫(yī)院老年病科收治的原發(fā)性高血壓患者121例，隨機分為纈沙坦組（n=60）和氨氯地平組（n=61）。纈沙坦組患者口服纈沙坦膠囊，1粒/次，1次/d。氨氯地平組患者口服苯磺酸氨氯地平片，1片/次，1次/d。兩組均連續(xù)治療12周。觀察兩組的臨床療效，同時比較兩組治療前后收縮壓、舒張壓、心率、總膽固醇（TC）、三酯甘油（TG）、低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）、脂聯素（APN）、一氧化氮（NO）、內皮素（ET）的變化情況。結果 氨氯地平組和纈沙坦組的總有效率分別為78.69%、80.00%，兩組比較差異無統(tǒng)計學意義。治療后，兩組患者收縮壓、舒張壓、心率、ET均顯著降低，APN、NO顯著升高，同組治療前后差異有統(tǒng)計學意義（P<0.05）。治療后，纈沙坦組心率低于氨氯地平組，APN水平高于氨氯地平組，兩組比較差異具有統(tǒng)計學意義（P<0.05）。結論 纈沙坦和氨氯地平治療原發(fā)性高血壓均具有較好的臨床療效，纈沙坦可提高患者血漿脂聯素水平，改善血管內皮功能，氨氯地平對脂聯素水平無顯著影響。

Objective To compare clinical curative effect of valsartan and amlodipine in treatment of primary hypertension. Methods Patients (121 cases) with primary hypertension in Department of Geratology of Beijing Chuiyangliu Hospital from December 2012 to December 2015 were randomly divided into valsartan (n=60) and amlodipine (n=61) groups. The patients in valsartan group were po administered with Valsartan Capsules, 1 grain/time, once daily. The patients in amlodipine group were po administered with Amlodipine Besylate Tablets, 1 tablet/time, once daily. The patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and the change of SBP, DBP, heart rate, TC, TG, LDL-C, HDL-C, APN, NO, and ET in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in amlodipine and valsartan groups were 78.69% and 80.00%, respectively, and there was no difference between two groups. After treatment, SBP, DBP, heart rate, and ET in two groups were significantly decreased, and APN, NO were significantly increased, and the difference was statistically significant in the same group (P<0.05). The heart rate in the valsartan group was lower than that in the control group; APN was higher than that in the control group, with significant difference between two groups (P<0.05). Conclusion Valsartan and amlodipine have clinical curative effect in treatment of primary hypertension, and valsartan can improve the level of plasma adiponectin, also can improve endothelial function, but amlodipine has no significant effect on adiponectin level.