目的 探討注射用尖吻蝮蛇血凝酶聯(lián)合注射用奧美拉唑鈉治療急性非靜脈曲張上消化道出血的臨床療效。方法 選取2013年6月-2015年1月商洛市中心醫(yī)院收治的急性非靜脈曲張上消化道出血的患者94例，依據(jù)治療方案隨機(jī)分為對照組和治療組，每組各47例。對照組靜脈滴注注射用奧美拉唑鈉，40 mg溶于100 mL葡萄糖溶液中，2次/d。治療組在對照組基礎(chǔ)上靜脈推注注射用尖吻蝮蛇血凝酶，1 U溶于20 mL生理鹽水中，2次/d。兩組均連續(xù)治療5 d。觀察兩組的臨床療效，比較兩組治療前后臨床癥狀和血紅蛋白（Hb）水平。結(jié)果 治療后，對照組和治療組的總有效率分別為82.90%、95.70%，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，治療組的止血時間、輸血量、住院時間、再出血率明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者Hb水平均明顯升高，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組Hb水平的升高程度明顯優(yōu)于對照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患者不良反應(yīng)均較為輕微，統(tǒng)計(jì)學(xué)差異不明顯。結(jié)論 注射用尖吻蝮蛇血凝酶聯(lián)合注射用奧美拉唑鈉治療急性非靜脈曲張上消化道出血具有較好的臨床療效，止血速度快，安全性高，不良反應(yīng)低，值得臨床推廣使用。

Objective To observe the clinical effect of Haemocoagulase Agkistrodon for injection combined with Omeprazole Sodium for injection in treatment of acute nonvariceal upper gastrointestinal bleeding. Methods Patients (94 cases) with acute nonvariceal upper gastrointestinal bleeding in Shangluo Central Hospital from June 2013 to January 2015 were selected. According to the different treatment methods, the patients were randomly divided into control and treatment group, and each group had 47 cases. The patients in the control group were iv administered with Omeprazole Sodium for injection, 40 mg added into glucose solution 100 mL, twice daily. The patients in the treatment group were iv administered with Haemocoagulase Agkistrodon for injection on the basis of the control group, 1 U added into normal saline 20 mL, twice daily. The patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and clinical symptoms and Hb levels in two groups were compared before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 82.90% and 95.70%, respectively, and there was difference between two groups (P<0.05). After treatment, bleeding time, blood transfusion, hospital stays, and rebleeding rate in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, Hb levels in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, Hb levels in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). Patients in two groups had mild adverse reaction, but there was no significant difference. Conclusion Haemocoagulase Agkistrodon for injection combined with Omeprazole Sodium for injection has clinical curative effect in treatment of acute nonvariceal upper gastrointestinal bleeding, fast bleeding, high safety, and low adverse reaction,, which has a certain clinical application value.