目的 探討仙靈骨葆膠囊聯(lián)合地奧司明治療腰椎間盤突出癥（LDH）的臨床療效。方法 選取2014年3月-2016年3月在荊州市第二人民醫(yī)院接受治療的LDH患者76例，隨機(jī)分為對(duì)照組（38例）和治療組（38例）。對(duì)照組口服地奧司明片，2片/次，3次/d。治療組在對(duì)照組基礎(chǔ)上口服仙靈骨葆膠囊，3粒/次，2次/d，兩組患者均連續(xù)治療4周。觀察兩組的臨床療效，同時(shí)比較兩組治療前后MPQ評(píng)分、ODI評(píng)分、腰椎關(guān)節(jié)活動(dòng)度、ADL評(píng)分、主要癥狀體征評(píng)分、血清TNF-α和IL-6水平的變化情況。結(jié)果 治療后，對(duì)照組和治療組的總有效率分別為84.21%、97.37%，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組MPQ評(píng)分、ODI評(píng)分、主要癥狀體征評(píng)分均明顯降低，而ADL評(píng)分升高，兩組血清TNF-α和IL-6水平均較治療前顯著下降，腰椎關(guān)節(jié)前屈與后伸活動(dòng)度均較同組治療前明顯增加，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療組這些觀察指標(biāo)的改善程度優(yōu)于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 仙靈骨葆膠囊聯(lián)合地奧司明治療LDH效果顯著，可明顯改善患者臨床癥狀和腰椎活動(dòng)度，并可降低血清炎性因子表達(dá)，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effect of Xianling Gubao Capsules combined with diosmin in treatment of lumbar disc herniation (LDH). Methods Patients (76 cases) with LDH in The Second Hospital of Jingzhou from March 2014 to March 2016 were randomly divided into control (38 cases) and treatment (38 cases) groups. The patients in the control group were po administered with Diosmin Tables, 2 tables/time, three times daily. The patients in the treatment group were po administered with Xianling Gubao Capsules on the basis of the control group, 3 grains/time, twice daily. The patients in two groups were treated for 4 weeks. After treatment, the clinical effect was evaluated. MPQ scores, ODI scores, lumbar joints activities, ADL scores, main symptoms and sings scores, serum TNF-α and IL-6 levels were compared between two groups. Results After treatment, the clinical efficacies in the control and treatment groups were 84.21% and 97.37%, respectively, and there were differences between two groups (P<0.05). After treatment, MPQ scores, ODI scores, main symptoms and sings scores, serum TNF-α and IL-6 levels in two groups were significantly decreased, ADL scores, lumbar joints flexion, and extension activities were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Xianling Gubao Capsules combined with Diosmin Tables has clinical curative effect in treatment of LDH, and can significantly improve the clinical symptoms and lumbar activities, also can reduce the expression of serum inflammatory factor, which has a certain clinical application value.