目的 探究胎盤(pán)多肽注射液聯(lián)合甘露聚糖肽預(yù)防骨折患者術(shù)后感染的療效觀察。方法 選取2014年1月-2015年1月在陜西省核工業(yè)二一五醫(yī)院接受骨折治療的80例患者，隨機(jī)分為對(duì)照組和治療組，每組各40例。對(duì)照組患者在基礎(chǔ)治療上靜脈滴注注射用甘露聚糖肽，10 mg加入5%葡萄糖250 mL中，1次/d。治療組患者在對(duì)照組治療基礎(chǔ)上靜脈滴注胎盤(pán)多肽注射液，8 mL加入生理鹽水250 mL，1次/d。兩組均連續(xù)治療14 d。比較兩組患者的住院時(shí)間、滲出液消失時(shí)間、感染控制時(shí)間、皮膚愈合時(shí)間、骨骼愈合時(shí)間、術(shù)后感染率等。同時(shí)比較兩組患者治療前后腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-1（IL-1）、白細(xì)胞介素-6（IL-6）、C-反應(yīng)蛋白（CRP）、白細(xì)胞計(jì)數(shù)（WBC）、CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺和NK細(xì)胞的變化情況。結(jié)果 治療后，治療組住院時(shí)間、滲出液消失時(shí)間、感染控制時(shí)間、皮膚愈合時(shí)間、骨骼愈合時(shí)間均顯著短于對(duì)照組，治療組術(shù)后感染率明顯低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組TNF-α、IL-1、IL-6、CRP、WBC均顯著降低，CD³⁺、CD⁴⁺、CD⁴⁺/CD⁸⁺、NK均顯著升高，同組治療前后差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；且治療后治療組這些觀察指標(biāo)的改善程度顯著優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 胎盤(pán)多肽注射液聯(lián)合甘露聚糖肽預(yù)防骨折患者術(shù)后感染具有較好的臨床療效，可以降低骨折患者的術(shù)后感染率，增強(qiáng)患者的免疫力，具有一定的臨床推廣應(yīng)用價(jià)值。

Objective To observe the clinical effects of Placenta Polypeptide Injection combined with mannatide in prevention of postoperative infection of fracture patients. Methods Patients (80 cases) with fracture in NO. 215 Hospital of Shaanxi Nuclear Industry from January 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 40 cases. The patients in the control group were iv administered with Mannatide for injection on the basis of treatment, 10 mg added into 5% glucose solution 250 mL, once daily. The patients in the treatment group were iv administered with Placenta Polypeptide Injection on the basis of the control group, 8 mL added into normal saline 250 mL, once daily. The patients in two groups were treated for 14 d. After treatment, the hospital stay time, exudates disappeared time, the infection control time, skin healing time, bone healing time, and postoperative infection rate in two groups were compared. And the changes of TNF-α, IL-1, IL-6, CRP, WBC, CD³⁺, CD⁴⁺, CD⁴⁺/CD⁸⁺ and NK in two groups before and after treatment were compared. Results After treatment, the hospital stay time, exudates disappeared time, the infection control time, skin healing time, bone healing time, and postoperative infection rate were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, TNF-α, IL-1, IL-6, CRP, and WBC were significantly increased, and CD³⁺, CD⁴⁺, CD⁴⁺/CD⁸⁺, and NK were significantly increased, and the difference was statistically significant in the same group (P<0.05). After treatment, those observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Placenta Polypeptide Injection combined with mannatide has clinical curative effect in prevention of postoperative infection of fracture patients, and can reduce the postoperative infection rate of patients with fracture, and enhance the immunity of patients, which has a certain clinical application value.